摘要
AIM: To explore the mechanisms of uncut Roux-en-Y gastrojejunostomy, which is used to decrease the occurrence of Roux stasis syndrome.METHODS: The changes of myoelectric activity, mechanic motility and interstitial cells of Cajal (ICC) of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy were observed. RESULTS: When compared with the cut group, the amplitude (1.15 ± 0.15 mV vs 0.48 ± 0.06 mV, P < 0.05) and frequency (14.4 ± 1.9 cpm vs 9.5 ± 1.1 cpm, P < 0.01) of slow waves and the incidence (98.2% ± 10.4% vs 56.6% ± 6.4%, P < 0.05) and amplitude (0.58 ± 0.08 mV vs 0.23 ± 0.06 mV, P < 0.01) of spike potential of the Roux limb in the uncut group were significantly higher. The migrating myoelectric complexes (MMC) phase Ⅲ duration in the uncut group was significantly prolonged (6.5 ± 1.1 min vs 4.4 ± 0.8 min, P < 0.05), while the MMC cycle obviously shortened (42.5 ± 6.8 vs 55.3 ± 8.2 min, P < 0.05). Both gastric emptying rate (65.5% ± 7.9% vs 49.3% ± 6.8%, P < 0.01) and intestinal impelling ratio (53.4% ± 7.4% vs 32.2% ± 5.4%, P < 0.01) in the uncut group were significantly increased. The contractile force index of the isolated jejunal segment in the uncut group was significantly higher (36.8 ± 5.1 vs 15.3 ± 2.2, P < 0.01), and the expression of c-kit mRNA was significantly increased in the uncut group (0.82 ± 0.11 vs 0.35 ± 0.06, P < 0.01). CONCLUSION: Uncut Roux-en-Y gastrojejunostomymay lessen the effects of operation on myoelectric activity such as slow waves, spike potential, and MMC, decrease the impairment of gastrointestinal motility, and remarkably increase the expression of c-kit mRNA.
AIM： To explore the mechanisms of uncut Roux-en-Y gastrojejunostomy, which is used to decrease the occurrence of Roux stasis syndrome. METHODS： The changes of myoelectric activity, mechanic motility and interstitial cells of Cajal （ICC） of the Roux limb after cut or uncut Roux-en-Y gastrojejunostomy were observed. RESULTS： When compared with the cut group, the amplitude （1.15 ± 0.15 mV vs 0.48 ± 0.06 mV, P 〈 0.05） and frequency （14.4 ± 1.9 cpm vs 9.5 ± 1.1 cpm, P 〈 0.01） of slow waves and the incidence （98.2% ± 10.4% vs 56.6% ± 6.4%, P 〈 0.05） and amplitude （0.58 ± 0.08 mV vs 0.23 ± 0.06 mV, P 〈 0.01） of spike potential of the Roux limb in the uncut group were significantly higher. The migrating myoelectric complexes （MMC） phase Ⅲ duration in the uncut group was significantly prolonged （6.5 ± 1.1 min vs 4.4 ± 0.8 min, P 〈 0.05）, while the MMC cycle obviously shortened （42.5 ± 6.8 vs 55.3 ± 8.2 min, P 〈 0.05）. Both gastric emptying rate （65.5% ± 7.9% vs 49.3% ± 6.8%, P 〈 0.01） and intestinal impelling ratio （53.4% ± 7.4% vs 32.2% ± 5.4%, P 〈 0.01） in the uncut group were significantly increased. The contractile force index of the isolated jejunal segment in the uncut group was significantly higher （36.8 ± 5.1 vs 15.3 ± 2.2, P 〈 0.01）, and the expression of c-kit mRNA was significantly increased in the uncut group （0.82 ± 0.11 vs 0.35 ± 0.06, P 〈 0.01）. CONCLUSION： Uncut Roux-en-Y gastrojejunostomy may lessen the effects of operation on myoelectric activity such as slow waves, spike potential, and MMC, decrease the impairment of gastrointestinal motility, and remarkably increase the expression of c-kit mRNA.
