NaHSO_4·SiO_2催化合成β-烯胺酮(酯)

Silica Supported Sodium Hydrogen Sulfate Catalyzed Efficient Synthesis of β-Enamino Ketones and Esters

NaHSO4·SiO2作催化剂,1,3-二羰基化合物和伯胺在室温下反应合成了一系列β-烯胺酮(酯),该法反应条件温和,产率高,催化剂能回收再利用.

Silica supported sodium hydrogen sulfate （NaHSO4·SiO2） has been found to be an efficient heterogeneous catalyst for the condensation of 1,3-dicarbonyl compounds with primary amines to give the corresponding β-enamino ketones and esters in good yields at room temperature. The catalyst could be easily recovered from the reaction mixture.