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肝豆状核变性的临床表现及其与误诊的关系分析 被引量:5

Relationships between Misdiagnosis of Wilson's Disease and Its Clinical Manifestations
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摘要 目的:分析肝豆状核变性(W D)临床表现及其与误诊关系。方法:对确诊的所有152例肝豆状核变性患者的性别、年龄、临床表现及误诊病种等因素进行分析。结果:(1)肝豆状核变性误诊与有无家族史有关,有阳性家族史者误诊率为6.89%,明显低于无家族史者(59.35%)(P<0.05);(2)以神经系统损害首发者误诊率为32.14%,较非脑病症状首发者为低(P<0.05);(3)以单个脏器功能损害首发时误诊率为56.92%,较两个或以上多器官功能损害并存时误诊率(4.55%)明显增高(P<0.05)。结论:肝豆状核变性误诊与临床表现的变化多样有关;有阳性家族史、出现神经系统症状或多器官损害并存时较少误诊。 Objective:To analyse the relationship between the misdiagnosis of Wilson's disease and its clinical manifestation,and improve the early diagnosis of Wilson's disease. Methods: 152 patients of Wilson's disease were explored to retrospective analysis the relationships between the misdiagnosis and gender,age,and the main clinical manifesations. Results: (1)Family history was closely associated with the misdiagnosis (P〈0.05). No significant associations were found between the misiagnosis and gender,age; (2)Lower misdiagnosis rate (32.14%) were found in the patients with nervous symptoms compared with that of non-nervous symptoms (P〈0.05); (3)The misdiagnosls rate in the patients with multirgans impairment (4.55 % )was significantly lower than that of single organ impairment (56.92%)(P 〈0. 05). Conclusions :The diversify of clinical manifestations of Wilson's disease is related to misdiagnosis ;Positive family history,nervous symptoms and multi organs impairment will be helpful to reduce the misdiagnosis rate.
出处 《中国误诊学杂志》 CAS 2007年第4期668-670,共3页 Chinese Journal of Misdiagnostics
关键词 肝豆状核变性/诊断 误诊 Hepatolenticular degeneration/diagnosis Diagnostic errors
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参考文献5

  • 1Sternlieb I.Willson's diseases[J].Clin Liver Dis,2000,4(1):229-239.
  • 2Huster D,Weizenegger M,Kress S,et al.Rapid detection of mutations in Wilson disease gene ATP7B by DNA strip technology[J].Clin Chem Lab Med,2004,42(5):507-510.
  • 3Ferenci P.Review article:diagnosis and current therapy of Wilson's disease[J].Aliment Pharmacol Ther,2004,19(2):157-165.
  • 4Prashanth LK,Taly AB,Sinha S,et al.Wilson's disease:diagnostic errors and clinical implications[J].J Neurol Neurosurg Psychiatry,2004,75(6):907-909.
  • 5梁秀龄,陈曦,李洵桦,黄丽,石铸,汤其强.肝豆状核变性临床若干问题[J].中华神经科杂志,2005,38(1):57-59. 被引量:54

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