仙仲注射液治疗原发膝OA临床疗效观察

Clinical Observation on Effect of Xian-Zhong Injection on Treating Primary Knee OA

目的：研究和评价仙仲注射液治疗原发膝OA临床价值。方法：127名非手术治疗原发膝OA患者按照Lequesne制定的膝骨性关节炎严重性指数（ISOA）及Kellgren—Lawrance（K—LA）X线分析标准不同分为轻、中、重三级。采用随机单盲对照方法，每级分成两组，分别关节腔注射施沛特、仙仲注射液进行观察；均为2ml（1次／周），连续注射四周。分别于治疗后1、3、6个月后随访，以后每6个月一次。结果：经过1—24个月随访，ISOA评分小于13分且K-IJA分级小于Ⅲ级，两种关节腔药物注射取得了很好的疗效；而评分大于13且分级在Ⅲ级以上，两种药物注射都没有取得较好效果。两组药物治疗后总有效率和优良率比较无明显差异性。结论：仙仲注射液可以提高治疗原发膝OA临床疗效，具有较大应用前景和研究价值。

Objective： To research and evaluate the clinical efficacy of Xian-zhong injection in treating primary knee OA. Methods： By using Lequesne instituted ISOA and Kellgren-Lawrance instituted X-ray class standard, 127 non-operation primaary knee OA patients were divided into three grades （Light, Moderate, Severe）. To adopt randomized single controlled triM, each grade was divided into two groups, respecitvely injected Xian-zhong injection or Sodium Hyaluronate injection. Every injection＇s volume was 2ml and in- jected one per week, then consecutively injected one month. Finally we followed up in the first month, third month, sixth month, afterward we did every six months. Results ： After followed up one - twenty-four months, we found ISOA score less than thirteen and K-LA X-ray class standard less than Ⅲ grade, the clinical efficacy of two kind of injections was better. But ISOA score more than thirteen and K-LA X-ray class standard mord than Ⅲ grade, the clinical efficacy was bad. The follow-up showed that the total effective rate and excellent rate between Xian-zhong injection group and Sodium Hyaluronate injection group weren＇t significantly different. Conclusion： Xian-zhong injection can improve the clinical efficacy of primary knee OA, it has the greatest researching value and using furthermore.