期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

一个AB型开米拉家系遗传状态的研究 被引量：5

Genetic Status of a AB Chimeric Blood Group Family
下载PDF
导出
摘要 为了研究罕见开米拉血型家系的基因遗传状态,对先证者家系部分样本进行ABO基因序列测定,用流式反向序列特异性寡核苷酸探针方法测定HLA-A、B、DRB1基因位点,用PCR-序列特异性引物法测定HLA-A、B、DRB1基因位点,对16个短串联重复片段位点进行荧光标记复合扩增。结果发现:A3B3型家系的2个体中,ABO基因、HLA-B、DRB1基因、多个STR位点出现了2个以上的等位基因。结论:利用基因分型技术分析开米拉血型能清楚地提示此罕见血型的遗传状态,增进了对此遗传方式的认识。 In order to study the genetic status of a rare chimeric family, some samples of A3B3 family were identified by sequencing of ABO gene; flow-rSSO and PCR-SSP were used to detect loci of HLA-A, B, DRB1 genes, and multiplex amplifying with fluorescence-dye were performed for 16 short tandem repeat （STR） loci. The results indicated that two individuals from AaB3 family contained more than two alleles at ABO gene, HLA-B,DRB1 and some STR loci. In conclusion, analysis of chimeric blood group by using genotyping techniques clearly demonstrating genetic status of this rare chimeric blood group promotes further elucidation of the existing state of specific genetic status.
作者 杨宝成 喻琼 苏宇清 周丹 金士正 李茜 梁延连 邓志辉
机构地区 深圳市血液中心
出处 《中国实验血液学杂志》 CAS CSCD 2007年第2期417-420,共4页 Journal of Experimental Hematology
基金 2006年广东省社会发展领域科技计划项目(编号63111)资助
关键词 开米拉血型 ABO HIA STR Chimeric blood group, ABO, HLA, STR
分类号 R457.11 [医药卫生—治疗学]
  • 相关文献

参考文献11

  • 1Race RR,Sanger R.Blood groups in man.Oxford:Blackwell Science.1975:511 -546
  • 2Daniels G.Human blood groups.Oxford:Blackwell Science.1995:684-692
  • 3Yu N,Kruskall MS,Yunis JJ,et al.Disputed maternity leading to identification of tetragametic chimerism.N Engl J Med,2002; 346:1545-1552
  • 4Olsson ML,Chester MA.Polymorphisms at the ABO locus in subgroup A individuals.Transfusion,1996; 36:309-313
  • 5Seltsam A,Hallensleben M,Kollmann A,et al.The nature of diversity and diversification at the ABO locus.Blood,2003; 102:3035 -3042
  • 6Olsson ML,Irshaid NM,Hosseini-Maaf B,et al.Genomic analysis of clinical samples with serologic ABO blood grouping discrepancies:identification of 15 novel A and B subgroup alleles.Blood,2001;98:1585-1593
  • 7喻琼,梁延连,邓志辉,吴国光,苏宇清,张旋,程良红.A_3等位基因的分子遗传分析[J].中国实验血液学杂志,2005,13(1):135-139. 被引量：8
  • 8Deng ZH,Yu Q,Wu GG,et al.Molecular genetic analysis for Ax phenotype at the ABO blood group system in Chinese.Vox Sang,2005; 89:251 -256
  • 9Thiede C,Florek M,Bornhauser M,et al.Rapid quantification of mixed chimerism using multiplex amplification of short tandem repeat markers and fluorescence detection.Bone Marrow Transplant,1999;23:1055-1060
  • 10Olsson ML,Chester MA.Heterogeneity of the blood group Ax allele:genetic recombination of common alleles can result in the Ax phenotype.Transfus Med,1998; 8:231 -238

二级参考文献11

  • 1Yamamoto F, Marken J, Tsuji T, et al. Cloning and characterization of DNA complementary to human UDP-GalNac: fuc alphal -2Gal alpha1 - 3GalNac transferse mRNA. J Bio Chem, 1990; 265:1146 - 1151
  • 2Olsson ML, Chester MA. Polymorphism and recombination events at the ABO locus: a major challenge for genomic ABO blood grouping strategies. Transfus Med, 2001; 11:295 - 313
  • 3Chester MA, Olsson ML. The ABO Blood Group Gene: a locus of considerable genetic diversity. Transfus Med Rev, 2001; 15:177 -220
  • 4Olsson ML, Chester MA. Polymorphisms at the ABO locus in subgroup A individuals. Transfusion, 1996; 36: 309 - 313
  • 5Blood Group Antigen Gene Mutation Database. http://www. bioc.aecom.. yu. edu/bgmut/abo. htm
  • 6Yamamoto F, McNeill Pd, Yamamoto M, et al. Molecular genetic analysis of the ABO blood group system 1: Weak Subgroups: A3and B3 alleles. Vox Sang, 1993; 64:116
  • 7Barjas-Castro ML, Saad ST. Absence of the G871A mutation in A3 blood donors from Brail. Transfusion, 1997; 37:564
  • 8Bajas-Castro ML, Carvalho MH, Locatelli MF, et al. Molecular heterogeneity of the A3 subgroup. Clin Lab Haematol, 2000; 22: 73-78
  • 9Sun CF, Yu LC, Chen IP, et al. Molecular genetic analysis for the Ael and A3 alleles. Transfusion, 2003; 43:1138 - 1144
  • 10萧星莆.输血技术手册[M].北京：人民卫生出版社,1995.494-505.

共引文献7

同被引文献36

  • 1Evans PC, Lambert N, Maloney S,et al. Long-term fetal mierochimerism in peripheral blood mononuelear cell subsets in healthy women and women with scleroderma. Blood, 1999,93 (6) :2033- 2037.
  • 2Bianehi DW, Ziekwolf GK, Weil GJ, et al. Male fetal progenitor cells persist in maternal blood for as long as 27years postpartum. Proc Natl Aead Sci USA, 1996,93(2):705-708.
  • 3Finning KM, Martin PG, Soothill PW, et al. Prediction of fetal D status from maternal plasma:introduction of a new noninvasive fetal RHD genotyping service. Transfusion, 2002,42 ( 8 ) : 1079- 1085.
  • 4Scaletti C, Vultaggio A, Bonifacio S, et al. Th2-oriented profile of male offspring T cells present in women with systemic sclerosis and reactive with matemal major histocompatibility complex antigens. Arthritis Rheum, 2002,46(2) :445-450.
  • 5Colson YL, Schuchert MJ, Ildstad ST, The abrogation of allosensitization following the induction of mixed allogeneic chimerism. J Immunol. 2000,165(2) :637-44.
  • 6Manolov G, Levan A, Nadkami JS, et al. Burkitt' s lymphoma with female karyotype in an African male child. Hereditas, 1970,66 ( 1 ) :79-100.
  • 7Thiede C, Florek M, Bornhauser M, et al. Rapid quantification of mixed chimerism using multiplex amplification of short tandem repeat markers and tluorescence detection. Bone Marrow Transplant, 1999,23(10) :1055-1060.
  • 8Pruss A, Heymann GA, Hell A, et al. Acute intravascular hemolysis after transfusion of a chimeric RBC unit. Transfusion, 2003,43(10) :1449-1451.
  • 9Yu N, Kruskall MS, Yunis JJ, et al. Disputed maternity leading to identification of tetragametic chimerism. N Engl J Med, 2002, 346 (20) : 1545-1552.
  • 10Dl'exler C, Clock B, Vadon M, et al. Tetragametie chimerism detected in a healthy woman with mixed-field agglutination reactions in ABO blood grouping. Transfusion, 2005,45 ( 5 ) : 698- 703.

引证文献5

二级引证文献16

中国实验血液学杂志
2007年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部