精神分裂症患者皮纹a-b嵴线数波动性不对称的研究

Fluctuating Asymmetry of Dermatoglyphic a-b Ridge Count in Individuals with Schizophrenia

本文分析了精神分裂症患者134例(男性70例,女性64例)和正常对照人群331例(男性170例,女性161例)皮纹a-b嵴线数波动性不对称的分布特征。结果表明:⑴精神分裂症患者双手皮纹a-b嵴线数明显低于正常对照组(P<0.01);⑵精神分裂症患者皮纹a-b嵴线数的波动性不对称水平与正常对照组存在显著性差异(t=2.668,P<0.01),表现出明显增高。

The purpose of this paper is to analyze the fluctuating asymmetry （FA） of dermatoglyphic a-b ridge counts in individuals with schizophrenia from Ningxia, China. Fluctuating asymmetry refers to small random deviations from perfect symmetry in bilaterally paired structures. It is the result from interactions between developmental disturbance and developmental stability, and it has a low heritability. Fluctuating asymmetry can be as a measure of individual quality and also an indicator of developmental stability. Computing FA was done using the absolute differences between bilateral measurements （ calculated as FA = ｜ R - L ｜ ）. Inked dermatoglyphic samples were collected from individuals who gave their informed consent, and the required parameters for this research were analyzed. A random sample was taken from 134 people with schizophrenia （70 male and 64 female） and compared with 331 healthy controls （170 male and 161 female）. The results were that （1） Individuals with schizophrenia had a reduced mean a-b ridge counts compared to the control group（ P 〈 0.01） ; （2） There was a significant difference between groups in FA of a-b ridge counts （t = 2.668, P 〈 0.01 ） with individuals with schizophrenia having a significantly higher fluctuating asymmetry of a-b ridge counts; （3） In a distribution of a-b ridge count, schizophrenia was significant different in the group of FA≥ 10. It may indicate that people with schizophrenia had a higher developmental instability in their earlier fetation. These results may indicate that during the course of fetal development, the schizophrenia fetus is much more sensitized to a variety of external environments.