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卡维地洛与美托洛尔治疗慢性心力衰竭短期疗效的对比研究 被引量:5

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摘要 目的 探讨卡维地洛与美托洛尔治疗慢性心力衰竭(CHF)患者的短期疗效。方法 将治疗后病情稳定的128例CHF患者随机分为卡维地洛组65例,美托洛尔组63例。在标准抗心力衰竭治疗的基础上,卡维地洛组加用卡维地洛口服,2次/d,首剂3.125mg/次,5~7d后增至6.250mg/次,后根据患者状态,每1~2周递增6.250mg/次,直至目标剂量25.000ms/次或患者最大耐受剂量。美托洛尔组加用美托洛尔口服,2次/d,首剂6.25mg/次,5~7d后增至12.50mg/次,后根据患者状态,每1~2周递增12.50mg/次,直至目标剂量50.00mg/次或患者最大耐受剂量。治疗8周后观察两组患者的临床疗效、剂量调整时间、达到目标剂量例数、静息心率、血压、左室射血分数(LVEF)、心输出量(CO)、心脏指数(CI)。结果 治疗后两组患者静息心率均降低,卡维地洛较美托洛尔更能有效地降低收缩压及舒张压,明显改善LVEF、CO、CI,更易达到目标剂量且剂量调整时间短,卡维地洛组显效率和总有效率明显高于美托洛尔组。结论 卡维地洛短期应用(8周)即可改善CHF患者的心功能,且剂量调整时间短,易达到目标剂量,短期疗效优于美托洛尔,值得临床推广。
作者 佟玉红
出处 《中国医师进修杂志(内科版)》 2007年第5期49-50,共2页 Chinese Journal of Postgraduates of Medicine
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