涎腺多形性腺瘤中雌激素受体和P53蛋白的表达相关关系的研究

RELATIONSHIP BETWEEN EXPRESSIONS OF ER AND P53 PROTEIN IN HUMAN MIXED TUMOR

[目的]探讨ER和P53蛋白表达与涎腺多形性腺瘤的临床病理关系。[方法]应用免疫组织化学方法检测多形性腺瘤中ER和P53蛋白的表达。[结果]在40例多形性腺瘤中,ER阳性者16例,表达率为40%(16/40);P53蛋白表达22例,其表达率为55%(22/40);ER阳性的P53蛋白阳性表达率高于ER阴性,具有统计学差异。[结论]ER阳性的多形性腺瘤与P53蛋白表达密切相关。ER和P53蛋白的表达与多形性腺瘤的预后(复发、恶变)密切相关。

[Objective] To ascertain clinical pathological relationship between distribution of estrogen receptor （ER）, p53 protein accumulation and mixed tumor. [Methods] Depressions of ER and p53 protein were detected by immanohistochemistry method. [Results] ER was identified in 16 eases of 40 patients with mixed tumor. The positive rate was 40%. P53 protein was seen in 22 cases. It＇s positive rate was 55%. ER positive cases had a significantly higher expression of p53 protein than ER negative cases, [Conclusions] The results demonstrates a consistent relationship between ER and p53 protein accumulation. And ER, P53 protein accumulation have eolse relation to prognosis of mixed trmor.