表皮囊肿癌变临床病理特点及文献复习

Squamous cell carcinoma arising in epidermoid cyst:A report of two cases and review of the literature

目的:研究和探讨表皮囊肿及其癌变的发病机理、临床病理特点、诊断和鉴别诊断及治疗。方法:对2例表皮囊肿癌变进行光镜观察,并复习相关文献。结果:2例表皮囊肿的囊壁内衬上皮出现异常增生,增生的细胞具有明显异型性,核深染,可见病理性核分裂像,呈典型鳞状细胞癌结构,并向周围组织浸润性生长。结论:表皮囊肿是一种常见的良性病变,极少癌变;其诊断主要依靠组织病理学;主要的治疗方法是手术切除,辅以局部放射治疗和(或)化疗。

To study and research the pathogenesis, clinical pathological features, diagnosis, differential diagnosis and treatment of the epidermoid cyst with cancerous changes. Methods： Two cases of epidermoid cyst and their malignant transformation into squamous cell carcinoma were examined with light microscopy and the related literatures were reviewed. Results ： The lining epithelial cells of the two epidermoid cysts proliferated abnormally. Partial proliferating cells presented atypical, hyperchromasia and pathological mitoses with typical squamous cell carcinoma and invasive growth. Conclusion ： Although the epidermoid cyst is extremely common benign lesion, neoplasia transformation of its epithelium is quite rare. Diagnosis of the tumor relies largely on histopathology. The regular therapy is surgical resection of the tumor, followed by local radiotherapy and/or chemotherapy .