从药代学和药效学的观点看什么是理想的吸入性激素
摘要
吸入性激素(ICS)是支气管哮喘(简称哮喘)长期治疗的一线药物。糖皮质激素(简称激素)是目前最有效的哮喘抗炎药物,但因为全身性不良反应使其长期应用受限。但ICS治疗哮喘的疗效仍不甚理想,全球哮喘防治创议(GINA)中推荐ICS单独使用仅适用于轻度持续哮喘。研究ICS的药代学和药效学规律对认识ICS治疗哮喘的有效性和安全性,指导临床用药和开发新型ICS极为重要。
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
2007年第7期484-486,共3页
Chinese Journal of Tuberculosis and Respiratory Diseases
参考文献12
-
1Colice GL. Pharmacodynamic and pharmacokinetic considerations in choosing an inhaled eortieosteroid. Treat Respir Med,2006,5 : 245 -253.
-
2Clark D J, Lipworth BJ. Dose-response of inhaled drugs in asthma. An update. Clin Pharmacokinet, 1997,32:58-74.
-
3Bateman ED, Boushey HA, Bousquet J, et al. Can guideline-defined asthma control be achieved? The gaining optimal asthma controL study. Am J Respir Crit Care Med,2004,170:836-844.
-
4Martin RJ, Szefler SJ, Chinchilli VM. Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med ,2002,165 : 1377-1383.
-
5Wilson AM, Lipworth BJ. Short-term dose-response relationships for the relative systemic effects of oral prednisolone and inhaled flutieasone in asthmatic adults. Br J Clin Pharmaeol, 1999,48: 579-585.
-
6Todd GR, Acerini CL, Ross-Russell R, et al. Survey of adrenal crisis associated with inhaled corticosteroids in the united kingdom. Arch Dis Child, 2002,87:457-461.
-
7Rohatagi S, Appajosyula S, Derendorf H, et al. Risk-benefit value of inhaled glucocorticoids : a pharmacokinetic/pharmacodynamic perspective. J Clin Pharmacol, 2004,44:37-47.
-
8Lipworth BJ, Jackson CM. Safety of inhaled and intranasal corticosteroids: lessons for the new millennium. Drug Saf, 2000, 23 : 11-33.
-
9Affrime MB, Kosoglou T, Thonoor CM, et al. Mometasone furoate has minimal effects on the hypothalamic-pituitary-adrenal axis when delivered at high doses. Chest,2000,118:1538-1546.
-
10Krishnaswami S, Hochhaus G, Mollmann H, et al. Interpretation of absorption rate data for inhaled fluticasone propionate obtained in compartmental pharmacokinetic modeling. Int J Clin Pharmacol Ther, 2005,43 : 117-122.
-
1廖秀阁.吸入信必可都保治疗哮喘的疗效观察[J].中外医学研究,2011,9(5):86-87. 被引量:2
-
2贾玲.60例支气管哮喘患儿的临床疗效观察[J].中国医药指南,2012,10(27):496-497. 被引量:1
-
3贺桂秋.孟鲁司特钠对轻度持续哮喘患儿治疗临床分析[J].中国伤残医学,2013,21(12):211-211. 被引量:1
-
4谢蒂立,王丹.中-大剂量吸入性激素致初发肺结核一例报告[J].遵义医学院学报,2008,31(3):299-300.
-
5曾飞球.吸入性激素治疗哮喘的观察[J].黑龙江医药科学,2002,25(5):30-31.
-
6赵明玉.吸入激素联合缓释茶碱与吸入激素联合长效β2受体激动剂治疗支气管哮喘的临床疗效比较[J].中国保健,2010(11):36-36.
-
7曾笑影.金银花液配合碳酸氢钠溶液预防吸入激素致口腔疾病的疗效[J].中国中医药现代远程教育,2016,14(7):102-103. 被引量:3
-
8褚福珍.庆大霉素辅助治疗反流性食管炎36例疗效观察[J].中国社区医师(医学专业),2010,12(27):45-45.
-
9金嫣,沈雪艳,沈华浩.IL-23与哮喘气道炎症关系的研究进展[J].细胞与分子免疫学杂志,2014,30(3):318-320. 被引量:4
-
10Henderson L.S.,Tenero D.M.,Baidoo C.A.,张媛.控释和速释卡维地洛用于高血压稳定患者的药代学和药效学比较[J].世界核心医学期刊文摘(心脏病学分册),2007,0(3):24-25.