新疆维吾尔族Rh血型特征

Investigation of the Characteristics of Rh Blood Group of Uygur Nationality in Xinjiang

本研究探讨新疆维吾尔族Rh血型特点。采用Rh血清学分型,改良抗球蛋白实验,氯仿/三氯乙烯吸收放散实验、RH上游盒、下游盒、杂合盒、D基因10个外显子,RHDψ假基因等检测1230份维吾尔族血样本。结果表明:RhD阴性频率为5.8%,未发现Del型。对72份RhD(-)样本进一步研究发现,ccee(57.02%)和Ccee(29.82%)表型,RHD-/RHD-基因型(94.44%)及D基因外显子全缺失型(91.12%)最常见。未发现RHDψ假基因。结论:我国新疆维吾洋族Rh血型兼有黄种人与白种人Rh特点。

The study was to investigate the characteristics of Rh blood group of Uygur nationalilty in Xinjiang. 1 230 blood samples of Uygur nationalilty were studied by Rh serological typing, modified antiglobulin test, chloroform/ trichloroethylene absorption elution test, upstream, downstream and hybrid Rhesus boxes, 10 exons of D gene, RH DΨpseudogene. The results showed that the frenquency of RHD negative was 5.8%, and no Del type was found. The further investigation of 72 samples of RhD（ - ） found that ccee（57.02 % ） and Ccee （ 29.08% ） phenotype as well as RHD^-/RHD^- genotype （94.44%） and complete deletion type of D gene exon （91.12%） were all in high frenquency, no RHDt~ pseudugene was detected. In conclusion, the Rh blood group of Uygurs nationality in Xinjiang possesses both oriental and caucasian Rh characterstics, which enriches the diversity of blood types in chinesenation.