套细胞淋巴瘤一例误诊分析

A Case Report of Misdiagnosed Mantle Cell Lymphoma

套细胞淋巴瘤(mantle cell lymphoma,MCL)是一类较少见的非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL),形态学方法常难以将其与其他类型小细胞淋巴瘤相鉴别。为了提高对MCL的认识,报道1例误诊为滤泡性淋巴瘤(follicular lymphoma,FL)的MCL,总结该病例临床资料及实验室检查特点。结果显示:流式细胞术(flow cytometry,FCM)及免疫组织化学染色检查符合MCL的特征,细胞遗传学检查发现了包括t(11;14)在内的多种染色体异常。结论:MCL为难以确诊的疾病,间期荧光原位杂交、多重荧光原位杂交、FCM以及免疫组织化学染色等检查有助于MCL的诊断。

Mantle cell lymphoma （MCL） is a rare group of non-Hodgkin＇s lymphoma （ NHL）, which is difficult to discriminate from other subtype of small lymphocytic lymphoma in morphologic appearance. In order to enhance the understanding of MCL, a case of MCL first diagnosed as follicular lymphoma （FL） was reported. The clinical and laboratory characteristics of MCL were analyzed and summarized. The results showed that the findings of flow cytometry （FCM） and immunohistochemical staining technique were compatible with the diagnosis of MCL. Cytogenetic analysis can detect multiple types of chromosomal abnormalities, including t（ 11 ： 14）. In conclusion, MCL is a disease which diagnosis is difficultly confirmed. Interphase fluorescence in situ hybridization, multiplex fluorescence in situ hybridization, FCM and immunohistochemical staining technique play important roles in the diagnosis of MCL.