卡维地洛与西拉普利联合应用治疗高血压合并冠心病90例疗效分析

Therapeutic effect of combined medication of Carvedilol and Cilazapril on patients with hypertension complicated with coronary heart disease:report of 90 cases

目的:探讨卡维地洛与西拉普利联合应用对高血压合并冠心病患者心率、血压、左室重构的影响及抗心绞痛作用.方法:以90例高血压合并冠心病患者为研究对象,采用彩色多谱勒超声技术,测定治疗前、后左室结构和功能,并临床观察、记录治疗前、后血压、心率的变化,心绞痛发作的次数及硝酸甘油的用量.结果:卡维地洛与西拉普利联合应用降血压、减慢心率、抗心绞痛、改善左室舒张功能、逆转左室肥厚等作用明显(P<0.05).结论:卡维地洛与西拉普利联合应用降压、抗心绞痛作用明显,且可全面阻断心室重构、改善心功能.

AIM： To study the anti-anginal efficacy of the com- bined medication of Carvedilol and Cilazapril on patients with hy- pertension and coronary heart disease, as well as its effects on heart rate, blood pressure, and left ventricular remodeling. METHODS： Ninety patients with hypertension complicated with coronary disease were included in this study. Color Doppler flow imaging was performed to evaluate the structure and function of left ventricle before and after the combined medication, Changes in blood pressure, heart rate and frequency of attacks as well as the dosage needed to control acute attack of angina were also do- cumented. RESULTS： Carvedilol and Cilazapril, when adminis- tered together, exerted a potent effect on slowing heart rate, relie- ving acute pain of angina pectoris, improving left ventricular dias- tolic function and reversing left ventricular hypertrophy （P 〈 0.05 ）. CONCLUSION ： The combined medication of Carvedilol and Cilazapril is effective not only in lowering blood pressure and treating angina pectoris, but also in improving ventricular function and preventing left ventricular remodeling.