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Syk与肿瘤侵袭和转移关系的研究进展 被引量：3

Advances in research of Syk in tumor invasion and metastasis
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摘要 蛋白酪氨酸激酶(protein tyrosine kinases,PTKs)是一类催化ATP上γ-磷酸转移到蛋白酪氨酸残基的激酶,能催化多种底物蛋白的酪氨酸残基磷酸化,在细胞生长、增殖及分化中具有重要作用。迄今发现的90余种PTKs具有癌基因功能,而Syk是目前发现的惟一具有抑癌作用的PTKs。近年来研究发现,Syk的表达与肿瘤的侵袭及转移密切相关。 Protein tyrosine kinases （PTKs） are enzymes that catalyze the phosphorylation of tyrosyl residues. They are important in the processes of cell growth, proliferation and differentiation. About 90 PTKs have the functions of oncogenes, while Syk is the only one which has antineoplastic function. It＇s found that there is a close correlation between the expression of Syk and tumor invasion and metastasis in recent researches.
作者 张春华 徐强 李胜
机构地区 山东省医学科学院研究生教育中心 山东省肿瘤医院肝胆外科
出处 《中华肿瘤防治杂志》 CAS 2008年第6期476-479,共4页 Chinese Journal of Cancer Prevention and Treatment
基金 国家自然科学基金(30600603) 山东省优秀中青年科学家科研奖励基金(2005BS03003) 山东省卫生厅项目(2005HW133)
关键词 肿瘤 基因 Syk 淋巴转移 淋巴管形成 综述文献 neoplasms genes, Syk lymphatic metastasis lymphangiogenesis review literature
分类号 R730.2 [医药卫生—肿瘤]
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参考文献28

  • 1Li X, Martin F, Oliver A M, et al. Antigen receptor proximal signaling in splenic B-2 cell subsets[J]. J Immunol,2001,166 (5):3122-3129.
  • 2Wang L, Duke L, Zhang P S, et al. Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer[J]. Cancer Res,2003,63(15):4724-4730.
  • 3Turner M, Mee P J, Costello P S, et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk[J]. Nature,1995,378(6554):298-302.
  • 4Turner M, Schweighoffer E, Colucci F, et al. Tyrosine kinase SYK: essential functions for immunoreceptor signaling[J]. Immunol Today, 2000,21 (3) : 148-154.
  • 5Jiang A,Craxton A,Kurosaki T,et al. Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase,c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase[J]. J Exp Med, 1998,188(7) : 1297-1306.
  • 6Craxton A,Jiang A, Kurosaki T,et al. Syk and Bruton's tyrosine kinase are required for B cell antigen receptor-mediated activation of the kinase Akt[J]. J Biol Chem,1999,274(43) :30644-30650.
  • 7Faruki S,Geahlen R L, Asai D J. Syk-dependent phosphorylation of microtubules in activated B-lymphocytes[J]. J Cell Sci,2000, 113 ( Pt 14):2557-2565.
  • 8Takano T, Sada K, Yamamura H. Role of protein-tyrosine kinase syk in oxidative stress signaling in B cells[J]. Antioxid Redox Signal,2002,4(3) :533-541.
  • 9Coopman P J,Do M T,Barth M,et al. The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells[J]. Nature, 2000,406 (6797) : 742-747.
  • 10Thompson E W, Paik S, Brunner N, et al. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines[J]. J Cell Physiol,1992,150(3):534-544.

二级参考文献16

共引文献27

同被引文献20

  • 1王艳,孙建国,叶明福,陈正堂.Podoplanin阳性淋巴管密度与非小细胞肺癌预后的关系[J].中华结核和呼吸杂志,2006,29(11):758-761. 被引量：8
  • 2丁永斌,夏建国,夏添松,陈国玉.Syk表达对胃癌细胞凋亡的影响[J].中国癌症杂志,2007,17(2):115-117. 被引量：8
  • 3王华毅,张兆祥.脾酪氨酸激酶与肿瘤[J].癌症,2007,26(5):555-560. 被引量：7
  • 4Kriehuber E, Breiteneder-Geleff S, Groeger M, et al. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages[J]. J Exp Med, 2001,194(6) :797-803.
  • 5Ichikura T,Tomimatsu S, Ohkura E, et al. Prognostic significance of the expression of vascular endothelial growth factor (VEGF) and VEGF-C in gastric careinoma[J]. J Surg Oneol, 2001,78 (2): 132- 136.
  • 6Bono P, Wasenius V M, Heikkila P, et al. High LYVE-l-positive lymphatic vessel numbers are associated with poor outcome in breast cancer[J]. Clin Cancer Res,2004,10(21):7144-7149.
  • 7Ji R C. Lymphalic endothelial cells, lymphangiogenesis,and extracellular matrix[J]. Lymphat Res Biol,2006,4(2):83-100.
  • 8Skobe M, Hawighorst T, Jackson D G, et al. Induction of tumor lympbangiogenesis by VEGF-C promotes breast cancer metastasis[J]. Nat Med, 2001,7(2):192-198.
  • 9Yonemura Y, Fushida S, Bando E, et al, Lymphangiogenesis and the vascular endothelial growth factor receptor (VEGFR)-3 in gastric cancer [J]. Eur J Cancer, 2001, 37(7) :918-923.
  • 10Ristimaki A, Narko K, Enholm B, et al. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth faetor-C[J]. J Biol Chem, 1998,273 (14): 8413-8418.

引证文献3

二级引证文献5

中华肿瘤防治杂志
2008年 第6期

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