期刊文献+

免疫法和化学法粪便隐血试验在上消化道出血性疾病中阳性率的比较 被引量:5

Positive rate comparison between immunological and chemical methods of fecal occult blood test in upper digestive tract bleeding
下载PDF
导出
摘要 目的:比较免疫法粪便隐血试验(immune fecal occult blood test,IFOBT)和化学法粪便隐血试验(chemical fecal occult blood test,CFOBT)在上消化道出血性疾病中的阳性率,以验证IFOBT筛查上消化道出血不具特异性.方法:2006-07/2007-03间连续选择我院内镜中心进行胃镜检查的上消化道出血性疾病患者206例,利用邻甲苯胺CFOBT和IFOBT同时比较两种粪便隐血试验的阳性率,并结合临床资料分析其相应结果.结果:IFOBT和CFOBT结果均与食管癌、胃癌的解剖部位及食管癌浸润深度无关,两者均与胃癌浸润深度有关,与胃癌的最大长径呈正相关(IFOBT:r=0.30,P=0.02:CFOBT:r=0.20,P=0.04);IFOBT与食管癌的最大长径呈正相关(r=0.38,P=0.01);CFOBT在食管癌患者中的阳性率高于食管磷状细胞癌抗原(SCC)的阳性率(47.43% vs 20.45%,P<0.05);两者在胃癌患者中的阳性率均高于CA125,CEA和CA199的阳性率.CFOBT检测胃癌、食管癌、返流性食管炎和消化性溃疡的阳性率均高于IFOBT(50.88% vs 35.09%,47.73% vs 29.55%,18.00% vs 6.00%,60.OO% vs 41.82%,均P<0.05).IFOBT在上消化道出血性疾病中的总阳性率低于CFOBT.结论:IFOBT粪便隐血试验不适合上消化道出血性疾病的筛查,可能对下消化道出血性疾病的筛查具有相对特异性. AIM: To compare the positive rates of immune fecal occult blood test (IFOBT) and chemical fecal occult blood test (CFOBT) in screening upper digestive tract bleeding. METHODS: A total of 206 consecutive patients who suffered upper digestive tract bleeding and underwent endoscopic examination in our hospital were chosen from July 2006 to March 2007. CFOBT (using o-toluidine) and IFOBT were used to detect fecal occult blood positive rate in the same fecal specimen, and comparison was made between the two methods. The positive rates were also analyzed combined with the clinical data. RESULTS: The results of IFOBT and CFOBT were not associated with anatomic sites in esophageal and gastric cancer, but associated with the invasion depth in gastric cancer, and they were positively correlated with the largest diameter of gastric cancer (IFOBT: r = 0.30, P = 0.02; CFOBT: r = 0.20, P = 0.04). Meanwhile, IFOBT result showed a positive correlation with the largest diameter of esophageal cancer (r = 0.38, P = 0.01). The positive rate of CFOBT was superior to that of squamous cell carcinoma (SCC) antigen detection in esophageal cancer patients (47.43% vs 20.45%, P 〈 0.05), and the positive rates of both methods were higher than those of CA125, CEA and CA199 detection. CFOBT was superior to IFOBT in detecting gastric cancer, esophageal cancer, reflux esophagitis and peptic ulcer (50.88% vs 35.09%; 47.73% vs 29.55%; 18.00% vs 6.00%; 60.00% vs 41.82%; all P 〈 0.05). The total positive rate of IFOBT was lower than that of CFOBT in detecting upper digestive tract bleeding. CONCLUSION: The IFOBT is not suitable for screening upper digestive tract diseases, but relatively specific for lower digestive tract bleeding.
出处 《世界华人消化杂志》 CAS 北大核心 2008年第9期946-950,共5页 World Chinese Journal of Digestology
基金 上海市重点学科建设资助项目 No Y0205~~
关键词 化学法粪便隐血试验 免疫法粪便隐血试验 上消化道出血 阳性率 Chemical fecal occult blood test Immune fecal occult blood test Upper digestive tract bleeding Positive rate
  • 相关文献

参考文献25

  • 1Autier P. Should organised faecal occult blood test screening be established? Ann Oncol 2002; 13:57-60
  • 2Honda K. Factors associated with colorectal cancer screening among the US urban Japanese population. Am J Public Health 2004; 94:815-822
  • 3Lowenfels AB. Fecal occult blood testing as a screening procedure for colorectal cancer. Ann Oncol 2002; 13:40-43
  • 4Rockey DC, Koch J, Cello JP, Sanders LL, McQuaid K. Relative frequency of upper gastrointestinal and colonic lesions in patients with positive fecal occult- blood tests. N Engl J Med 1998; 339:153-159
  • 5Wong WM, Lam SK, Cheung KL, Tong TS, Rozen P, Young GP, Chu KW, Ho J, Law WL, Tung HM, Choi HK, Lee YM, Lai KC, Hu WH, Chan CK, Yuen MF, Wong BC. Evaluation of an automated immunochemical fecal occult blood test for colorectal neoplasia detection in a Chinese population. Cancer 2003; 97:2420-2424
  • 6Strul H, Arber N. Fecal occult blood test for coloxectal cancer screening. Ann Oncol 2002; 13:51-56
  • 7Bleiberg H. Hemoccult should no longer be used for the screening of colorectal cancer. Ann Oncol 2002; 13:44-46
  • 8Crespi M, Lisi D. Is colorectal cancer screening by fecal occult blood feasible? Ann Oncol 2002; 13:47-50
  • 9张国祥,许文龙,楚旭.免疫法粪便潜血试验用于上消化道出血性疾病诊断的评价[J].江西医学检验,2007,25(4):381-382. 被引量:15
  • 10Nakama H, Zhang B. Immunochemical fecal occult blood test is inadequate for screening test of stomach cancer. Dig Dis Sci 2000; 45:2195-2198

二级参考文献32

  • 1武子涛,李世荣,韩英.粪便隐血试验在大肠癌筛检中的作用[J].华北国防医药,2004,16(5):305-307. 被引量:8
  • 2Villa E. Molecular screening for colon cancer detection.Dig Liver Dis, 2000, 32:173-177.
  • 3Muller O. Identification of colon cancer patients by molecular diagnosis. Dig Dis, 2003, 21: 315-319.
  • 4Zheng S, CAI S. Colorectal Cancer Epidemiology and Prevention Study in China. The Chinese-German Journal of Clinical Oncology, 2003, 2: 72-75.
  • 5Marshall KG. Population-based fecal occult blood screening for colon cancer: will the benefits outweigh the harm? CMAJ, 2000, 163: 545-546.
  • 6Wong BC, Chan AO, Wong KW, Ching CK, Wong WM,Tam S, Lai KC, Chan CK, Yuen MF, Lam SK. A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong. Eur J Cancer Prey, 2005, 14: 181-184.
  • 7Zheng S, Chen K, Liu X, Ma X, Yu H, Chen K, Yao K,Zhou L, Wang L, Qiu P, Deng Y, ZhangS. Cluster randomization trial of sequence mass screening for colorectal cancer. Dis Colon Rectum, 2003, 46: 51-58.
  • 8Colquhoun P, Newstead G, Weiss EG, Efron J, Nogueras JJ, Vemava AM 3rd, Wexner SD. Colorectal cancer screening: do they practice what they preach? ANZ J Surg, 2003, 73: 1028-1031.
  • 9Yusoff IF, Hoffman NE, Ee HC. Colonoscopic surveillance after surgery for colorectal cancer. ANZ J Surg, 2003, 73: 3-7.
  • 10Lau P, Sung J. Screening for colorectal cancer. Chin J Dig Dis, 2004, 5: 87-92.

共引文献22

同被引文献37

引证文献5

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部