NiCl_2·6H_2O催化下3-氟-4’-乙基联苯的合成

Synthesis of 3-fluorin-4' ethylbiphenyl catalyzed by NiCl_2·6H_2O

在Suzuki偶联反应中用NiCl2.6H2O催化剂合成3-氟-4’-乙基联苯。当反应温度为85℃,催化剂用量0.1 g,碳酸钾用量2 g,四丁基溴化铵用量0.1 g,甲苯40 mL,反应9 h,目标产物收率达到67.5%。

NiCl2·6H2O was applied in the Suzuki aryl-coupling reaction for preparing 3-fluorin-4＇ ethylbiphenyl. When the reaction temperature 85 ~C, the catalyst 0.1 g, the potassium carbonate 2 g, and the tetrabutylammonium bromide 0.1 g, toluene 40 mL, reaction time 9 h, the yield of 3-fluorin-4＇ ethylbiphenyl was 67.5%.