HIV/AIDS患者外周血CD4+、CD8+、CD3+淋巴细胞与血液各组份相关性的研究

RESEARCH ON CORRELATION AMONG CD4+,CD8+,CD3+ T LYMPHOCYTE AND ALL COMPONENTS OF HUMAN PERIPHERAL BLOOD IN HIV/AIDS PATIENTS

[目的]评价HIV/AIDS患者外周血CD4+、CD8+、CD3+淋巴细胞与血液各组份白细胞(WBC)、总淋巴细胞(TLC)、红细胞(RBC)、血红蛋白(HGB)、血小板(PLT)的相关性。[方法]采用Spearman秩和相关回顾性分析297例HIV感染者TLC和CD4+/CD8+/CD3+T淋巴细胞数的相关性。[结果]297例HIV感染者/AIDS患者血中CD4+淋巴细胞与血液中各组份的相关关系均有统计学意义,但只与TLC、WBC呈中度相关相关系数分别为0.576、0.423,与其他各组分呈弱相关;对CD4+淋巴细胞分组(CD4+﹤200/μl、200/μl≤CD4+﹤500/μl、CD4+≥500/μl)后,随着淋巴细胞计数的增加,血液各细胞值低于正常值的百分比减少;按患者和感染者来分组后,除RBC和HGB外,患者CD4+细胞与血液各组份的相关关系均较感染者高;经中西医联合治疗后,患者CD4+细胞与WBC、TLC、RBC、HGB相关性更强。297例HIV/AIDS患者血中CD3+、CD8+淋巴细胞与血液中各组份的相关关系均有统计学意义,其中与WBC呈中度相关,相关系数分别为0.495、0.425;与TLC呈强相关,相关系数分别为0.875、0.777。[结论]HIV/AIDS患者外周血,尤其是AIDS患者CD3+、CD4+、CD8+淋巴细胞与血液TLC相关性较强,可以将其作为反映HIV/AIDS患者机体免疫状况及疾病发展阶段的一个指标。

[Objective] To evaluate the relationship between CD3＋, CD4＋, CD8＋ T lymphocytes and all kinds of components in human peripheral blood such as white blood corpuscle （WBC）, total lymphocytes （TLC）, red blood cell （HGB）, platelet （PLT） in HIV/AIDS patients. [Methods] The relationship between TLC and CD4/CD8/CD3 T lymphocyte of 297 HIV-infected individuals were retrospectively analyzed by Spearman rank correlation. [ Results] The relationship between CD4＋ T lymphocytes and all kinds of components in human blood of 297 HIV/AIDS patients was statistically significant, but there was only a median relationship among CD4＋ T lymphocytes, TLC and WBC. The correlation coefficient was 0.576 and 0.423 respectively. There was a poor correlation between CD4＋ T lymphocytes and other components. If we divided the patients into three groups by CD4＋ T lymphocytes （CD4＋ 〈 200/μl, 200/μl≤CD4＋ 〈 500/μl, CD4＋≥500/μl）. Along with the increase of the lymphocyte count, the percentage of the value of all kinds of celia in blood decreased. If we divided the patients into two groups by patients and infectors, except RBC and HGB, the relationship between CD4＋ T lymphocytes and all kinds of components in human blood of patients was better than that of infectors. After the combined cure of traditional Chinese and Western medicine, the relationship among CD4＋ T lymphocytes, WBC, TLC, RBC and HGB was stronger. In the blood of 297 HIV/AIDS patients, the relationship between CD3＋, CD8＋ T lymphocytes and all kinds of components in human blood were statistically significant. There was a median correlation with WBC and the correlation coefficient was 0.495 and 0.425 respectively. There was a strong correlation with TLC, and the correlation coefficient was 0.875 and 0.777 respectively. [ Conelution ] The relationship between CD3＋, CD4＋, CD8＋ T lymphocytes in the peripheral blood of HIV/AIDS patients especially in the AIDS patients and all kinds of components in human blood is strong. We can use it as a index for the immune condition and the development stage of the disease in HIV/AIDS patients.