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3,3,7,7,9-五甲基-1,5-二氧螺[5.5]十一烷-8-酮的核磁共振研究

Study on 3,3,7,7,9-Pentamethyl-1,5-dioxaspiro[5.5]undecan-8-one by Nuclear Magnetic Resonance Spectroscopy
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摘要 以1,3-环己二酮为起始原料,经过3步合成,得到了适用于多种天然产物合成中的关键中间体3,3,7,7,9-五甲基-1,5-二氧螺[5.5]十一烷-8-酮。利用红外光谱、元素分析以及1H与13CNMR确定了目标化合物的准确结构;利用二维核磁共振技术1H-1HCOSY、NOESY、HMBC以及HSQC,对其1H和13CNMR进行了全归属,并得到了目标化合物的空间结构相关信息。 Being recognized as a key intermediate in the synthesis of many kinds of natural products,3,3,7,7,9-pentamethyl-1,5-dioxaspiro[5.5]undecan-8-one was successfully synthesized and it was characterized by IR,MS,^1H and ^13C NMR.The chemical shifts of^ 1H and ^13C NMR were fully assigned via several kinds of 2D NMR experiments such as ^1H-^1H COSY,NOESY,HMBC and HSQC.At the same time,the steric configuration of the title product was determined by NOESY.
作者 张成路 朱小磊 许永廷 程钰杰 牛铭明 陈颂
机构地区 辽宁师范大学化学化工学院
出处 《分析化学》 SCIE EI CAS CSCD 北大核心 2008年第7期975-978,共4页 Chinese Journal of Analytical Chemistry
基金 辽宁省科学技术研究基金(No05L202)资助项目
关键词 3 3 7 7 9-五甲基-1 5-二氧螺[5.5]十一烷-8-酮 核磁共振波谱 结构解析 天然产物 3,3,7,7,9-pentamethyl-1,5-dioxaspiro[5.5]undecan-8-one,nuclear magnetic resonance spectroscopy（NMR）,structure analysis,natural product
分类号 R91 [医药卫生—药学]
  • 相关文献

参考文献9

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二级参考文献15

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分析化学
2008年 第7期

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