番茄红素对去卵巢大鼠骨质疏松拮抗作用

Antagonistil effect of lycopene on osteoporosis in ovariectomized rats

目的探讨番茄红素对去卵巢骨质疏松模型大鼠股骨的密度、骨矿含量的影响。方法将72只15周龄SD大鼠随机分为6组,空白组做假手术,其余5组做卵巢切除术,术后用药12周后处死,测定右侧股骨骨密度、骨矿含量、血清雌二醇、碱性磷酸酶含量及子宫湿重。结果番茄红素高[20mg/(kg.bw)]、中[15mg/(kg.bw)]、低剂量组[10mg/(kg.bw)]、尼尔雌醇组[1.05mg/kg.bw)]能对抗骨密度、骨矿含量、血清雌二醇的下降、血清碱性磷酸酶的升高,与模型组比较,P<0.05;番茄红素各剂量组、尼尔雌醇组能对抗子宫指数的减轻,与模型组比较,P<0.05。结论番茄红素可以改善骨质量,抑制大鼠去卵巢骨质疏松的发生。具有类似雌激素的效应。

Objective To study and analyze the effect of lycopene on osteoporosis of ovariectomized rat model. Methods Seventy - two 15 - week - old SD rats were divided into six groups, included control group and five ovariectomized model groups. The model groups were fed with different - dose lycopene[ 10, 15,20 mg/（ kg· bw） ] for 12weeks. Then related indexes including length bone mineral density, bone mineral, serum estradiol, sertum ALP and uterus index were analyzed. Results Compared with model group, three different dose groups and nilestriol[ 1.05mg/（ kg·bw）] group showed increased bone mineral density, bone mineral, serum estradiol and uterus index, but decreased serum ALP （ P 〈 0.05）. Conclusion As a female sex hormone - like component, lycopene may ameliorate the bone quality and inhibit osteoporosis in ovariectomized rat.