西宁地区急性重症脑出血昏迷患者应用奥德金治疗的疗效观察

Clinical Efficacy of Adegold for Coma Patients with Acute Serious Cerebral Hemorrhage in Xining Area

目的：观察奥德金注射液对西宁地区急性重症脑出血昏迷患者的神经功能恢复的疗效。方法：观察80例急性重症脑出血昏迷患者（格拉一斯哥昏迷评分在7～10分之间），随机分为治疗组和对照组各40例，对照组给予甘露醇等常规治疗2周，治疗组在常规治疗的基础上给予奥德金注射液30mL·d^-1，观察两组治疗2周后格拉-斯哥昏迷评分变化、头颅CT血肿量和脑水肿情况及治疗后清醒时间，并对其进行统计分析。结果：两组患者格拉-斯哥昏迷评分及头颅CT血肿量和脑水肿情况治疗前后比较有显著性差异（P〈0．05），治疗后对两组患者格拉-斯哥昏迷评分、头颅CT血肿量和脑水肿情况及清醒时间进行比较，两组间有显著性差异（P〈0．05）。结论：急性重症脑出血昏迷患者尽早应用奥德金可促进血液吸收，减轻脑水肿，缩短昏迷时间，促进神经功能恢复。

OBJECTIVE： To observe the clinical efficacy of Adegold on neural functional recovery in coma patients with acute serious cerebral hemorrhage in Xining area. METHODS： 80 patients with acute serious cerebral hemorrhagic coma （7- 10 scores evaluated by Glasgow Coma Scale） were enrolled： 40 cases （control group） were randomly assigned to receive Mannitol injection for 2 weeks as a routine treatment, 40 （treatment group） to receive Adegold injection （30 mL · d^-1） for 2 weeks plus routine treatment. After 2 weeks＇ treatment, Glasgow Coma Score, cerebral hemorrhagic amount and brain edema on brain CT and awake time of the two groups were observed and analyzed statistically. RESULTS The differences in Glasgow Coma Scale, cerebral hemorrhagic amount and brain edema on brain CT in the two groups before and after treatment were significant （ P 〈 0.05 ）. There were also significant differences between the two groups in Glasgow Coma Scale, cerebral hemorrhagic amount and brain edema on brain CT and awake time after treatment （ P 〈 0.05）. CONCLUSION Early application of Adegold in coma patients with acute serious cerebral hemorrhage can promote blood absorption, relieve brain edema, shorten coma time and promote neural functional recovery.