亚贡叶的化学成分研究

Studies on chemical constituents from leaves of Smallanthus sonchifolius

目的研究新引种的抗糖尿病植物亚贡Smallanthus sonchifolius叶的化学成分。方法应用多种柱色谱方法进行分离和纯化，NMR和MS等波谱解析化合物结构。结果从亚贡叶的乙醇提取物中分离出6个化合物，其结构分别鉴定为：5，8-二羟基-（5H，8H）-β-紫罗兰醇（Ⅰ）、对映-贝壳杉烷-3β，16β，17-三醇（Ⅰ）、对映-贝壳杉烷-16β，17-二醇-19-酸（Ⅲ）、3，4-二羟基苯甲醛（Ⅳ）、正二十五醇（Ⅴ）和正二十八醇（Ⅵ）。结论化合物Ⅱ～Ⅵ均为首次从本植物中分离得到，化合物Ⅰ为首次发现的β-紫罗兰醇型新化合物，命名为亚贡醇（sonchifolol）。

Objective To study the chemical composition from leaves of Smallanthus sonchifolius. Methods Some chromatography methods were used in the isolation procedure, while the structures were determined on the aids of NMR and MS spectral analyses. Results A new compound, together with five known compounds, was isolated from the ethanolic extract of the leaves. The new compound is characterized as 5, 8-dihydroxyl-（5H, 8H）-β-ionol （ Ⅰ）. Other compounds are obtained for the first time from the title plant and identified as ent-kaurane-3β, 16β, 17-triol （ Ⅱ ）, ent-kaurane-16β, 17-diol-19-oic acid （Ⅲ ）, 3, 4-dihydroxybenzaldehyde （ Ⅳ ）, 1-pentacosanol （ Ⅴ ）, and 1-octacosanol （ Ⅵ ）, respectively. Conclusion Compounds Ⅰ -Ⅵ are isolated from the plants of genus Smallanthus for the first time. Compound I is a β-ionol derivate firstly isolated from genus Smallanthus. It is named as sonchifolol.