加用舒血宁对不同抗精神病药物疗效及不良反应的影响

COMBINED USE OF GINKGO BILOBA EXTRACTS ON THE EFFICACY AND ADVERSE REACTIONS OF VARIOUS ANTIPSYCHOTICS

本研究旨在探讨银杏叶提取物（舒血宁）与不同抗精神病药物之间的协同作用。针对慢性精神分裂症病人，在既往抗精神病药物治疗不变的条件下加用舒血宁，进行多中心双盲安慰剂对照研究。结果发现，舒血宁与抗精神病药物的协同作用在不同药物有所不同。舒血宁增强氯氮平、氯丙嗪、舒必利对精神分裂症的总体疗效，增强氯氮平、舒必利对阴性症状的疗效。同时舒血宁能减轻氯氮平所致的不良反应如流涎和便秘。结果提示，在氯氮平治疗过程中最适合加用舒血宁以增强疗效。

The aim was to see the combined effect of antipsychotics and ginkgo biloba extracts (EGb 761). It was designed as a multicenter double-blind placebo controlled study on chronic schizophrenics with argumentation of EGb 761 with their previous used antipsychotics remaining unchanged. It was found that the augmentation effect of EGb761 on antipsychotics was different among different antipsychotic drugs. It increased the overall effect of clozapine,chlorpromazine,and sulpiride on schizophrenia. Furthermore, it increased the efficacy of clozapine, sulpiride on the negative symptoms of schizophrenia. EGb 761could also reduce the adverse reactions of clozapine like salivation,akathesia and constipation. We concluded that EGb 761 may be added in clozapine treatment in order to get higher efficacy and fewer adverse effects.