高危型人乳头状瘤病毒感染与卵巢上皮癌相关因素的分析

The Analysis on the Association between High-Risk Human Papillomavirus and Epithelial Ovarian Carcinoma

目的探讨高危型人乳头状瘤病毒感染与卵巢上皮癌的关系。方法选择经术后病理确诊的90例标本,其中卵巢上皮癌30例、卵巢上皮良性肿瘤30例、卵巢正常组织30例。采用第二代杂交捕获法来检测高危型HPV-DNA病毒。结果①30例卵巢上皮癌中高危型HPV(HPV16,HPV18)阳性11例(36.67%);卵巢上皮性良性肿瘤中高危型HPV(HPV16,HPV18)阳性2例(6.67%);正常卵巢组织中无1例阳性。②卵巢上皮癌组与卵巢上皮良性肿瘤组、正常卵巢组织的高危型HPV(HPV16,HPV18)感染率相比,均有显著性差异(χ2=7.95,P<0.05;χ2=13.47,P<0.05)。③卵巢上皮良性肿瘤与正常卵巢组织的HPV(HPV16,HPV18)感染率相比,两者无显著性差异(χ2=1.40,P>0.05)。④卵巢上皮癌组织中7例(23.33%)HPV16阳性,4例(13.33%)HPV18阳性,两者比较无显著性差异(χ2=1.001,P>0.05)。结论高危型HPV的感染可能与卵巢上皮性癌有关。

Objective To investigate the relationship between the infection of High-risk human papillomavirus（HPV）and epithelial ovarian carcinoma.Methods High risk HPV DNA was detected in the specimen from 30 patients with epithelial ovarian carcinoma,30 patients with benign epithelial ovarian tumors and 30 normal epithelial ovarian tissues by HC-Ⅱfrom January 2005 to December 2005.Results ①High-risk HPV（HPV16,HPV18）were positive in 11（36.67%）patients with epithelial ovarian carcinomas,2 cases（6.67%）with benign epithelial ovarian tumors.Non of the 30 normal tissues had positive HPV16 and HPV18.②The positive rate of high risk（HPV HPV16,HPV18）was significantly different between epithelial ovarian carcinomas,benign epithelial ovarian tumors and normal epithelial ovarian tissues（χ^2=7.95,P〈0.05;χ^2=13.47,P〈0.05）.③No significant difference of high-risk HPV（HPV HPV16,HPV18）existed between the benign epithelial ovarian tumors and normal epithelial ovarian tissues on（χ^2=1.40,P〉0.05）.④HPV16 were positive in 7（23.33%）and HPV18 in 4（13.33%）of ovarian carcinoma respectively,and there was no significant difference between the positive rates of HPV16 and HPV18（χ^2=1.001,P〉0.05）.Conclusion The infection of High-risk HPV may be related to the development of epithelial ovarian carcinoma.