血浆同型半胱氨酸与脑血管病相关性研究进展被引量：16

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摘要脑血管病是一种高发病率、高复发率、高致残率、高死亡率、高医疗费用的疾病，因而也是一种高社会负担的重大疾病。我国现有脑卒中生存患者达700万人．且以年发生156～234万人的速度在增长，每年夺去78-187万人的生命，已成为国人死亡的首因。众多研究认为高血压、糖尿病、冠心病、高脂血症、吸烟、饮酒等是脑血管病的主要的危险因素。近年来大量研究表明，

作者谢荣李金贤牛晓珊

机构地区新疆自治区人民医院康复医学科新疆自治区人民医院神经内科

出处《中国康复医学杂志》 CAS CSCD 北大核心 2008年第11期1056-1056,I0003,I0004,共3页 Chinese Journal of Rehabilitation Medicine

基金新疆维吾尔自治区卫生厅青年科研基金

关键词脑血管病血浆同型半胱氨酸高死亡率重大疾病高发病率高复发率医疗费用社会负担

分类号 R743 [医药卫生—神经病学与精神病学] R587.1 [医药卫生—内分泌]

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参考文献28

1叶辉,邵娇梅,蒋键刚,赵春霞,张帆,汪道文.血同型半胱氨酸与心脑血管疾病关系随访研究[J].心脏杂志,2006,18(1):60-61. 被引量：31
2Dong F,Zhang X,Li SY, et al. Possible involvcmcnt of NADPH oxidascand in homocysteine induced oxidative stress and apoptosis human umbilical vein endothelial cells[J].Cardiorasc Toxicol,2005,5( 1):9-20.
3Yano H, Nakaso K,Yasui K,et al. Mutations of the MTHFR gene (438C > T and [ 458G > T + 459C > T]) markedly decrease MTHFRenzyme activity [J]. Neurogenetic,2004,5 (2): 135-140.
4Kohara, Fujisawa,Ando, et al. MTHFR gene polymorphism as a risk factor for silent brain infarcts and white matter lesions in the Japanese general population: The NILS-LSA Study [J]. Stroke, 2003, 34(5):1130-1135.
5叶辉,严江涛,邵娇梅,张帆,洪茂林,汪道文.血浆同型半胱氨酸水平及亚甲基四氢叶酸还原酶基因突变与脑卒中关系的病例对照研究[J].中华流行病学杂志,2004,25(11):958-961. 被引量：32
6Gillum R. Distribution of serum total homocysteine and its association with diabetes and cardiovascular risk factors of the insulin resistance syndrome in Mexican American men: the Third National Health and Nu trition Examination Survey[J]. Nutr, 2003, 2:61.
7Refsum H, Smith AD, U eland PM, et al. Facts and recommendations about total homocysteine determinations: an expert opinion[J].Clin Chem, 2004,50: 320-321.
8Sacco RL, Anand K, Lee HS, et al. Homocysteine and the risk of ischemic stoke in a triethnic cohort:the Northern Manhattan Study[J]. Stroke, 2004, 35(10):2263-2269.
9Temple ME, Luzier AB, Kazierad DJ. Homocysteine as a risk factor for atherosclerosis [J]. Ann Pharmacother, 2000, 34:57- 65.
10Sasaki T, Watanabe M, Nagai Y, et al. Association of plasma homocysteine concentration with atherosclerotic carotid plaques and lacunar infarction[J]. Stroke, 2002, 33: 1493-1496.

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二级参考文献31

1叶辉,严江涛,邵娇梅,张帆,洪茂林,汪道文.血浆同型半胱氨酸水平及亚甲基四氢叶酸还原酶基因突变与脑卒中关系的病例对照研究[J].中华流行病学杂志,2004,25(11):958-961. 被引量：32
2张林华,刘秉文.一次性密度梯度超速离心分离人血清脂蛋白[J].生物化学与生物物理学报,1989,21(3):257-260. 被引量：116
3Herrmann W.The importance of hyperhomocysteinemia as a risk factor for diseases:an overviw[J].Clin Chem Lab Med,2001,39(8):666-674.
4Blundell G,Jones BG,Rose FA,et al.Homocysteine mediatedendothelial cell toxicity and its amelioration[J].Arteriosclerosis,1996,122(2):201 -216.
5Sparrow CP,Olszewski J.Cellular oxidation of low density lipoprotein is caused by thiol production in media containing transition metalions[J].J Lipid Res,1993,34(7):1219-1228.
6Stamlen JS,Osborn JA.Adverse affects of homocysteine are modulated by endothelium derived relaxing factor and related oxides of nitrogen[J].J Clin Invest,1993,91:308 -318.
7Tanne D,Haim M,Goldbourt U,et al.Prospective study of serum homocysteine and risk of ischemic stroke among patients with preexisting coronary heart disease[J].Stroke,2003,34 (3):632 -636.
8Howard VJ,Sides EG,Newman GC,et al.Changs in plasma homocysteine in the acute phase after stroke[J].Stroke,2002,33 (2):473-478.
9Bos MJ,van Goor ML,Koudstaal PJ,et al.Plasma homocysteine is a risk factor for recurrent vascular events in young patients with an ischaemic stroke or TIA[J].J Neurol,2005,252 (3):332-337.
10黄一宁,高山,王莉鹃,汪波.闭塞性脑血管病经颅多谱勒超声和脑血管造影的比较[J].中华神经科杂志,1997,30(2):98-101. 被引量：176