摘要
5-Fluorouracil（5-FU） loaded nanoparticles（NPs） were prepared by a high speed shearing double emulsion method with polylactide-co-glycolide-co-methoxy poly（ethylene glycol）（PLGA-mPEG） as loading material. The prepared NPs possess a negative zeta potential and their loading efficiency is about 15%（mass fraction）. The result of in vitro release shows that the release behavior of 5-FU from NPs is coincident with Zero-level release from the second day.
5-Fluorouracil（5-FU） loaded nanoparticles（NPs） were prepared by a high speed shearing double emulsion method with polylactide-co-glycolide-co-methoxy poly（ethylene glycol）（PLGA-mPEG） as loading material. The prepared NPs possess a negative zeta potential and their loading efficiency is about 15%（mass fraction）. The result of in vitro release shows that the release behavior of 5-FU from NPs is coincident with Zero-level release from the second day.
基金
Supported by the National Natural Basic Research Program of China(No. 2007CB80800)
the Special Foundation of Harbin Technical Innovation for Talental Person(No. 2006RFQXS075)
