中分子羟乙基淀粉扩容效果的实验研究被引量：9

The expanding capacity of hydroxylethyl starch in rabbits

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摘要目的探讨6%羟乙基淀粉(6%HES200/0.5)的扩容效果。方法10只健康成年新西兰兔,125I-IgG标准计数后,自家兔耳缘静脉注射3min充分混匀,取血少许称重测量放射量计数,约2ml测量血红蛋白(Hb),并在20min内近心端静脉匀速输注6%HES200/0.510ml/kg;输入后取约2ml血再次测量Hb。计算中分子羟乙基淀粉输注后新西兰兔血容量和扩容系数。结果兔血容量Vi125(V1)为(232.5±38.9)ml;V2为(280.4±44.6)ml,6%HES200/0.5扩容量ΔV为(48.9±0.4)ml。结论中分子羟乙基淀粉在输注20min后显示明显扩容效果。 Objective To explore the expanding capacity of hydroxylethyl starch （6% HES200/0.5） in rabbits. Methods The expanding capacity of 6 0%HES200/0.5 was studied in 10 healthy adult New Zealand rabbits by injecting 10 ml/kg ^125 I- IgG-laheled 6% HES200/0.5 via the ear vein within 20 min and two ml of blood was taken for measuring the radicalization and haemacbrome （Hb）, respectively. Results Blood volume Vi125 （V1） was （232.5±38.9） ml, V2 was （280.4±44.6） ml, the △V （expanding volume by 6%HES200/0.5） was （48.9±0.4） ml,the correction factor ：K=1. 97. Conclusion The infusion of 6% HES200/0.5 sbowes obvious expanding capacity at 20 min after infusion.

作者郭锋杨志杨拔贤范志毅徐兵

机构地区北京大学临床肿瘤学院、北京肿瘤医院暨北京市肿瘤防治研究所麻醉科北京大学临床肿瘤学院、北京肿瘤医院暨北京市肿瘤防治研究所核医学科北京大学人民医院麻醉科

出处《临床麻醉学杂志》 CAS CSCD 2008年第11期973-975,共3页 Journal of Clinical Anesthesiology

关键词 ^125I-IgG 血容量羟乙基淀粉 ^125I- IgG Blood volume Hydroxylethyl starch

分类号 R96 [医药卫生—药理学]

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