摘要
目的:观察肝豆片Ⅰ号治疗肝豆状核变性(HLD)临床疗效及对其24h尿微量元素的影响。方法:口服肝豆片Ⅰ号治疗 34例 HLD 4周,密切观察患者症状、体征及日常生活的变化,并测定患者治疗前及治疗后每周 24h尿微量元素含量。结果:总有效率为 70.59%,显效率为8.82%。对儿童及(或)病情较轻的患者疗效较好。治疗后每周的24h尿排铜量均较治疗前显著增加( P< 0.01);虽然其 24h尿排铜量和疗程是负相关( r=- 0.96; P< 0.05),但是治疗后各周之间的 24h尿排铜量两两比较无明显差异(P>0.05),故其尿排铜作用无减弱。结论:肝豆片Ⅰ号治疗 HLD有效,能促进 HLD尿铜的排泄,且未见明显毒副作用。
Objective: To investigate the efficacy of HLD-Tablet I in treating hepatolenticular degeneration (HLD) and its effect on urinary trace element in 24 hours. Methods: After 4 weeks of treatment on 34 cases of HLD by oral taken HLD -Tablet I, the clinical practice was closely observed on the patients' change of spoptoms, signs and daily life pattern, and measured the level of urinary trace element in 24 hours before the therapy and after that every week. Results: The total effective rate reached 70.59 %, marked effective rate was 8.82 %. The effect of treatment was better in the infantile and mild patient. After treatment, the daily output of urinary copper was obviously increased every week than that before (P <0.01 ). It was highly negative linear correlated with the duration of treatment (r = -0.96, P <0.05 ). But it was insignificantly different between any two weekly excretions of urinary copper per 24 hours after treatment by the HLD-Tablet I (P >0.05), so its effect on urinary copper excretion was not decreased. Conclusion: The HLD-Tablet I could increase the output of urinary copper, hence it was effective in treating HLD without apparent toxic or side reaction.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1998年第1期12-14,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金!(No 39570878)
关键词
肝豆状核变性
肝豆片Ⅰ号
微量元素
中医药疗法
hepatolenticular degeneration, HLD-Tablet I, urinary trace element in 24 hours