1988～1999年龙岩市出生人群甲型肝炎免疫水平调查

Investigation on Immunity Level Against Hepatitis A among Public Born in Longyan City from 1988 to 1999

[目的]了解龙岩市1988～1999年出生人群甲肝免疫水平,为制订甲肝防治策略提供科学依据。[方法]采用分层随机抽样方法,各县（市、区）抽取3个乡镇,每个乡镇随机抽查1988～1999年出生的儿童90名,采用统一的调查表进行问卷调查,每人采集静脉血5 ml采用ELLSA法测定甲肝抗体（抗-HAVIgG）。[结果]调查1925名1988～1999年出生儿童,检测1925份血清,抗-HAVIgG阳性的621份,阳性率为32.3%。男童阳性率为30.1%（303/1006）,女童为34.6%（318/919）,差异有统计学意义（P〈0.05）。不同年龄组间抗-HAV IgG阳性率的差异有统计学意义（P〈0.01）。不同地区间抗-HAVIgG阳性率的差异有统计学意义（P〈0.01）。[结论]龙岩市该人群抗-HAVIgG阳性率显著低于1992～1995年全国和全省HAV流行率水平,今后应继续加强预防甲肝知识的宣传,并提高该人群甲肝疫苗接种率。

[Objective]To Study Immunity Level against Hepatitis A among people born from 1988 to 1999,in order to provide scientific basis for making prevention and control strategy, [Methods]3 villages were extracted from each county, and 90 children born from 1988 to 1999 were extracted from each village with stratified random sampling method. The questionnaire survey was carried on through unification survey form. 5mL venous blood was drawn to examine anti-HAV IgG with ELISA. [Results] 925 serum samples collected from 1 925 children born from 1988 to 1999 were tested, 621 were anti-HAV IgG positive,positive rate was 32.3%. The positive rate among male children was 30.1% （303/1 006） while among female children was 34.6 % （318/919）. The difference of anti-HAV IgG positive rate had statistics significance between different age group, different area（ P 〈0. 05）. [Conclusion]The anti-HAV IgG positive rate of people born from 1988 to 1999 was obviously lower than the HAV prevalence level of the whole country and Fujian province from 1992-1995. Propaganda on hepatitis A prevention knowledge should be strengthened from now on, and hepatitis A vaccination coverage must be improved.