摘要
传统的抗心律失常药物的应用,由于心外不良反应和潜在的致心律失常作用而在心房颤动的治疗中受到限制,由于目前对心房电生理和结构改变的进一步认识以及不断研发新药,新的药物如胺碘酮衍生物、选择性心房离子通道阻滞剂及缝隙连接调节剂得以问世,现就心房颤动药物治疗进展作简要概述。
Management of atrial fibrillation with antiarrhythmic drugs traditionally has been hindered by poor tolerance of side effects, drug-associated toxicity, and proarrhythmic potential. Improved understanding of atrial electrical and structural remodeling as well as advances in rational drug design have led to the appearance of new agents such as amiodarone derivatives, atrium-selective channel blockade, and gap junction modulators. This review discusses recent advances in pharmaeotherapy for treatment of atrial fibrillation.
出处
《心血管病学进展》
CAS
2009年第2期294-296,共3页
Advances in Cardiovascular Diseases
