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p53-dependent and independent apoptosis induced by ionizing radiation in murine bone marrow cells 被引量:2

p5 3-dependent and independent apoptosis induced by ionizing radiation in murine bone marrow cells
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摘要 APOPTOSIS or programmed cell death is a model of cell death, along with typical morphological and biochemical changes. The cell death, occurring during embryonic development, T and B cell maturation and endocrine-induced atrophy, is a physiological apoptosis which controls the amount of cells in the body. Apoptosis can also be induced by various factors, such as ionizing radiation and anti-tumour agents which damage DNA, and has been proposed to be a consequence of the induced expression of some tumour-related genes or increase of the proteins sta-
出处 《Chinese Science Bulletin》 SCIE EI CAS 1997年第2期155-159,共5页
关键词 apoptosis p53 KNOCK-OUT mouse bone MARROW cells ionizing radiation. apoptosis p53 knock out mouse bone marrow cells ionizing radiation
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  • 1周平坤,魏康.用脉冲电场凝胶电泳检测电离辐射所致哺乳动物细胞DNA双链断裂[J].生物化学杂志,1991,7(5):513-517. 被引量:7
  • 2Williams GT,Smith CA.Molecular regulation apoptosis: genetic controls on cell death. Cell . 1993
  • 3Lowe SW,Schmitt EM,Smith SW,et al.p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature . 1993
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  • 6Tamura, T,Ishihara, M,Lamphier, M. S. et al.IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature . 1995

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