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THE ROLE OF ONCOGENES AND ONCO-SUPPRESSOR GENES IN CARCINOGENESIS

THE ROLE OF ONCOGENES AND ONCO-SUPPRESSOR GENES IN CARCINOGENESIS
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摘要 Carcinogenesis is a multi-stage process.This process may involve both genetic and epi-genetic events. Analyses of the involvement ofgenetic events (mutations in the global sensewhich include point mutations, deletions, trans-locations and rearrangements of genetic mate-rial) in carcinogenesis have implicated twomajor classes of genes, oncogenes and onco-suppressor genes. Oncogenes, a term first usedby Huebner and Todaro, are derived by muta-tion of normal cellular genes, protooncogenes.More than 40 oncogenes have now been isolatedand found to encode proteins with diverse bio-chemical functions.
出处 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1989年第1期73-77,共5页 中国癌症研究(英文版)
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  • 1Demetrios A. Spandidos.A unified theory for the development of cancer[J]. Bioscience Reports . 1986 (8)
  • 2Friend SH,et al.A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature . 1986
  • 3Yokota J,et al.Alterations of myc, myb and ras Ha proto-oncogenes in cancer are frequent and show clinical correlation. Science . 1986
  • 4Whyte P,et al.Association between an oncogene and an anti-oncogene: the adenovirus ElA proteins bind to the retinoblastoma gene product. Nature . 1988
  • 5Spandidos DA.Mechanisms of carcinogenesis:the role of oncogenes transcriptional enhancers and growth factors. Anticancer Research . 1985
  • 6Barbacid M.Ras genes. Annual Review of Biochemistry . 1987
  • 7Noda M,et al.Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes. Proceedings of the National Academy of Sciences of the United States of America . 1983
  • 8Norton JD,et al.Expression of Kirsten murine sarcoma virus in transformed non-producer and revertant NIH/3T3 cells.Evidence for cell-mediated resistance to a viral oncogene in phenotypic reversion. Journal of Virology . 1984
  • 9Meilink F,et al.Removal of a 67 base pair sequence in the non-coding region of the protooncogene fos converts it to a transforming gene. Proceedings of the National Academy of Sciences of the United States of America . 1985
  • 10Liu E,et al.Mutations of the kirsten-ras proto-oncogene in human preleukemia. Nature . 1987

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