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SELECTIVE KILLING OF GASTRIC CANCER CELLS BY MONOCLONAL ANTIBODY CONJUGATED WITH A CHAIN OF RICIN

SELECTIVE KILLING OF GASTRIC CANCER CELLS BY MONOCLONAL ANTIBODY CONJUGATED WITH A CHAIN OF RICIN
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摘要 A specific cytotoxic agent against gastric cancer was constructed by covalently coupling the ricin A chain to monoclonal artibody, MGb2. MGb2 was modified by SPDP to introduce the 3-(2-pyridylthio) propionyl radical and then treated with a reduced A chain to give a disulfide linked conjugate that retained the original binding specificity of the antibody moiety. The conjugate obtained retained the activity of the antibody and the biological activity of the A chain well. A specific cytotoxic agent against gastric cancer was constructed by covalently coupling the ricin A chain to monoclonal artibody, MGb2. MGb2 was modified by SPDP to introduce the 3-(2-pyridylthio) propionyl radical and then treated with a reduced A chain to give a disulfide linked conjugate that retained the original binding specificity of the antibody moiety. The conjugate obtained retained the activity of the antibody and the biological activity of the A chain well.
出处 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 1989年第3期37-41,共5页 中国癌症研究(英文版)
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