伊曲康唑对比氟康唑治疗老年恶性肿瘤合并深部真菌感染的研究

Comparative Study of Itraconazole and Fluconazole in the Treatment of Old Patients with Malignant Tumor and Deep Fungal Infection

目的对比观察伊曲康唑和氟康唑治疗老年恶性肿瘤患者合并深部真菌感染的疗效和安全性。方法选择2003年～2007年老年恶性肿瘤合并深部真菌感染患者共46例，其中伊曲康唑组和氟康唑组各23例，分别按照相应的指导用法进行治疗。结果伊曲康唑组总有效率为78．3％，氟康唑总有效率仅为47．8％，二者之间差异有显著性（P〈0．05）,而伊曲康唑组的不良反应率为26．1％，氟康唑组的不良反应率为13．0％，二者之间差异无显著性（P〉0．05）。结论对老年恶性肿瘤合并深部真菌感染患者，应用伊曲康唑治疗较氟康唑治疗更有效，副作用却未明显增加。

Objective To observe the efficacy and safety of Itraconazole and Fluconazole in the treatment of forty six old patients with malignant tumor and invasive fungal infection.Methods From 2003 to 2007,forty six old patients with malignant tumor and deep fungal infection were devided into two groups,and administered by Itraconazole and Fluconazole respectively.Results In Itraconazole group,the overall response rate was 78.3%,which was significantly higher than that of Fluconazole group（47.8%）.The side effects rate of Itraconazole group was 26.1% and the side effects rate of Fluconazole group was 13.0%.But there were no significant differences between the side effects rate of the two groups.Conclusion Itraconazole,which did not show higher side effects rate,was more effective than Fluconazole in the treatment of old patients with malignant tumor and deep fungal infection.