摘要
The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation （HGAP） process. Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment （rotating packed bed） in carrying out the anti-solvent precipitation process to produce nanoparticles. The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles. The Brunauer-Emmett-Teller （BET） surface area sharply increases from 0.66 m^2·g^-1 to 15.08 m^2·g^-l. Accordingly, the dissolution rate is greatly improved. The molecular state, chemical composition, and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared （FTIR） and X-ray diffraction （XRD）, The high recovery ratio and continuous production capacity are highly appreciated in industry. Therefore, the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.
The nanoparticles of the hydrophobic drug of danazol with narrow size distribution are facilely prepared by controlled high-gravity anti-solvent precipitation(HGAP) process.Intensified micromixing and uniform nucleation environment are created by the high-gravity equipment(rotating packed bed) in carrying out the anti-solvent precipitation process to produce nanoparticles.The average particle size decreases from 55 μm of the raw danazol to 190 nm of the nanoparticles.The Brunauer-Emmett-Teller(BET) surface area sharply increases from 0.66 m2·g-1 to 15.08 m2·g-1.Accordingly,the dissolution rate is greatly improved.The molecular state,chemical composition,and crystal form of the danazol nanoparticles remains unchanged after processing according to Fourier transform infrared(FTIR) and X-ray diffraction(XRD).The high recovery ratio and continuous production capacity are highly appreciated in industry.Therefore,the HGAP method might offer a general and facile platform for mass production of hydrophobic pharmaceutical danazol particles in nanometer range.
基金
Supported by the National High Technology Research and Development Program of China (2006AA030202)
the Talent Training Program of Beijing (2007B022)
