七叶皂苷治疗脑出血

Aescine in treatment of cerebral hemorrhage

目的：研究七叶皂苷（昔名七叶皂甙）治疗脑出血的疗效。方法：７１例经头颅ＣＴ证实的脑出血病人随机分为治疗组３７例，男性１６例，女性２１例，年龄５９±ｓ７ａ，七叶皂苷１０ｍｇ溶于０．９％氯化钠注射液２５０ｍＬ中静脉滴注，并常规治疗（甘露醇、青霉素等）；对照组３４例，男性１５例，女性１９例，年龄５８±７ａ，常规治疗；２组均治疗１４ｄ。结果：治疗组总有效率８７％高于对照组（５６％），Ｒｉｄｉｔ分析Ｐ＜０．０５；且治疗组脑血流量、血液流变学及过氧化物歧化酶改善，血肿吸收加快，对照组不明显。结论：七叶皂苷治疗脑出血有效。

AIM: To study the efficacy of aescine in treatment of cerebral hemorrhage. METHODS: Seventy_one patients with cerebral hemorrhage were randomly divided into two groups: (A) 37 patients (M 16, F 21; age 59±s 7 a) were treated with aescine 10 mg in 250 mL of 0.9% sodium chloride injection, iv, drip, qd, in addition to conventional therapy(mannitol, penicillin, etc). (B) 34 patients (M 15, F 19; age 58±7 a) treated with conventional therapy. The therapeutic course was 14 d. RESULTS: The total response rates (87%) of group A was superior to that of group B (56%), by Ridit analysis, P<0.05. After treatment the hemorrheology, cerebral blood flow and SOD was obviously improved in group A, but those in group B were not changed. CONCLUSION: Aescine has a good effect for treatment of cerebral hemorrhage.