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人表皮生长因子受体4在13种实体瘤中的表达 被引量：2

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摘要 HER4是由癌基因erbB4编码的第四人体表皮生长因子受体。本研究旨在检测HER4在13种实体肿瘤中的表达，探讨HER4过度表达与这些肿瘤临床生物学行为之间的关系。
作者 邓在春 虞亦鸣 胡居根 邓人健 白图门 陈鲧 刘忠 谭云山 徐永华
机构地区 宁波大学附属医院 宁波鄞州医院 江西省奉新县医院 复旦大学附属中山医院 中科院上海细胞所
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2009年第7期946-946,共1页 Chinese Journal of Experimental Surgery
基金 宁波市卫生局资助项目（2002057）
关键词 人表皮生长因子受体 实体瘤 临床生物学行为 HER4 实体肿瘤 ERBB4 过度表达 癌基因
分类号 R737.9 [医药卫生—肿瘤]
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参考文献8

  • 1Lai C, Lemke G. An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron, 1991,6:691-704.
  • 2Plowman GD, Culouscou JM, Whitney GS, ct al. Ligand-specific activation of HER4/ P180erbB4,a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci USA, 1993,90 : 1746-1750.
  • 3Jacobs TW,Gown AM,Yaziji H,et al. Specificity of hercep test in determing Her-2/ NEU status of breast cancers using the United States food and drug administrationapproved scoring system. Journal of Clinical Oncology, 1999,17 : 1983-1987.
  • 4Srinivasan R, Poulsom R, Hurst HC, et al. Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. J Pathol, 1998,185:236.
  • 5Kataoka H,Joh T, Kasugai K, et al. Expression of mRNA for heregulin and its receptor,ErbB-3 and ErbB-4, in human upper gastrointestinal mucosa. Life Sci, 1998,63:553-564.
  • 6虞亦鸣,周浩杰,谭云山,徐永华,刘忠,邓在春.erbB4／HER4在胃癌的表达[J].中华实验外科杂志,2008,25(1):41-41. 被引量：7
  • 7Tovey SM, Dunne B, Witton C J, et al. HER4 in breast cancer:comparison of antibodies against intra-and extra-cellular domains of HER4. Breast Cancer Res, 2006,8:19.
  • 8Tang CK, Concepcion XZ, Milan M, et 8.1. Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo. Cancer Res, 1999,59: 5315-5322.

二级参考文献7

  • 1Jacobs TW,Gowll AM,Yaziji H,et al. Specificity of hercep test in determing her- 2/ NEU status of breast cancers using the united states food and drug administration- approved scoring system. Journal of Clinical Oncology, 1999,17 : 1983.
  • 2Plowman GD, Culouscou JM, Whitney GS, et al. Ligand-specific activation of HER4/ P180erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci USA, 1993,90 : 1746.
  • 3Srinivasan R,Poulsom R, Hurst HC, et al. Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types. J Pathol,1998 ,185 :236.
  • 4Li W,Park JW,Nuijens A,et al. Heregulin is rapidly translocated to the nucleus and its transprot is correlated with c-myc induction in breast cancer cells. Oncogene, 1996,12:2473.
  • 5Junttila TT, Sundvall M, Lundin M, et al. Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells. Cancer Res ,2005,65 : 1384.
  • 6Kountourakis P,Pavlakis K,Psyrri A,et al. Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas, BMC Cancer ,2006,28:6:46.
  • 7邢传平,刘斌,董亮.免疫组织化学标记结果的判断方法[J].中华病理学杂志,2001,30(4):318-318. 被引量：206

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中华实验外科杂志
2009年 第7期

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