摘要
目的研究JAK1、p-STAT3和bcl-2在胃癌中的表达及与胃癌发生、发展的关系。方法采用免疫组织化学二步法检测JAK1、p-STAT3和bcl-2在60例胃癌组织和60例胃镜标本中的表达。结果(1)JAK1、p-STAT3和bcl-2的阳性表达率在胃癌中最高,其次是不典型增生和癌旁胃黏膜,再次是慢性萎缩性胃炎伴肠上皮化生,浅表性胃炎中最低(P<0.05);(2)胃癌JAK1、p-STAT3和bcl-2蛋白的阳性表达强度与分化程度、浸润深度、淋巴结转移、远端转移和临床分期有关(P<0.05);(3)胃癌中三种蛋白的阳性表达强度呈正相关(P<0.05)。结论JAK1、p-STAT3和bcl-2在胃癌组织中存在异常高表达并与胃癌发生、浸润、转移和临床分期有关。
Objective To study the relationship between the expressions of JAK1, p-STAT3 and bcl-2 and the tumorigenesis and development of human gastric cancer. Methods Immunohistochemical methods are used to detect the expressions of JAK1, p-STAT3 and bcl-2 in 60 gastric cancer tissues and 60 gastrosco- py tissues. Results （1）The positive ratio of JAK1, p-STAT 3 and bcl-2 expression were different in different tissues： gastric cancer 〉 atypical hyperplasia and adjacent mucosa〉 chronic atrophic gastrtis with intestinal metaplasia 〉superficial gastritis （P〈0. 05）; （2）In gastric cancer the positive intensities of JAK1, p-STAT 3 and bcl-2 expression were associated with differentiations, depth of tumor invasion, lymph node metastasis, distant metastasis and clinical stages （F〈0. 05） ;（3）The expressions of these three proteins were positive correlation （P〈0. 05）. Conclusion The JAK1, p-STAT 3 and bcl-2 were overexpressed in gastric cancer tissues compared with normal gastric tissues and related to its oncogenesis, invasion, metastasis and clinical stages closely.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2009年第8期657-661,共5页
Cancer Research on Prevention and Treatment
基金
内蒙古自治区自然科学基金资助项目(20080404MS1137)
内蒙古自治区高等学校科学研究资助项目(NJ09115)
