季节性对称性肢端角化症29例临床分析

Clinical analysis on 29 cases with seasonal symmetrical acrokeratoderma

目的:分析29例对称性肢端角化症患者的临床表现。方法:通过对2003年9月至2008年9月来我所就诊的29例对称性肢端角化症患者的人口学资料、临床表现及病理的分析,总结其临床及病理特征。结果:29例患者起病多为青壮年,皮损特点为对称分布的红褐色角化性斑片(29/29),多发于手腕、手背,遇水皮肤发白,有明显的季节性变化。病理学表现为角化过度、棘层肥厚、真皮浅层血管周围淋巴细胞浸润。结论:本组病例是否为一种新的皮肤病,或是进行性对称性红斑角化的一种亚型有待于进一步的研究。

Objective： To report a group of patients characterized by seasonal symmetric acrokeratoderma. Method： Twenty - nine patients characterized by acrokeratoderma were collected from outpatients during a period of September 2003 to September 2008. Their demographic information, family history, clinical manifestations and histopathology were analyzed. Result： The onset of the disease in this group of patients occurred at age of young adult. The skin lesions were characterized by red- brownish hyperkeratotic patches, which were primarily symmetrically distributed on wrists and dorsal hands. Skin became bleaching after exposure to water and underwent seasonal change. Histopathological examination showed hyperkeratosis, acanthosis and perivascular infiltrate of lymphocytes in the dennis. Conclusion： These patients may represent a new entity or a subtype of progressive symmetric erythrokeratoderma.