阿托伐他汀对不同阶段血管性认知功能障碍患者认知功能及血脂的影响

Effect of atorvastatin on cognition and blood lipids in patients with different stages of vascular cognitive impairment

目的探讨阿托伐他汀对不同阶段血管性认知功能障碍患者认知功能及血脂的影响。方法选取血管性认知功能障碍(VCI)患者140例,随机分为治疗组75例,其中无痴呆血管认知功能障碍(VCIND)患者47例,血管性痴呆(VaD)患者28例;对照组65例,其中VCIND患者41例,VaD患者24例。对照组给予常规治疗,治疗组在常规治疗基础上每晚加服阿托伐他汀20 mg,比较不同阶段的VCI患者治疗前后TC、TG、LDL-C、HDL-C及简易智能状态检查表(MMSE)、画钟试验分数等指标。结果治疗组VCIND和VaD患者治疗后TC、TG、LDL-C、MMSE、画钟试验的指标改善优于治疗前和对照组(P<0.01),VCIND患者治疗后MMSE、画钟试验评分差值明显高于VaD组(P<0.01),血脂变化无显著差异。结论阿托伐他汀调脂治疗的同时能改善VCI患者的认知功能,改善VCIND患者认知功能的作用优于VaD患者。

Objective To study the effects of atorvastatin on cognition and bloo＇d lipids in patients with different stages of vascular cognitive impairment（VCI）. Methods 140 patients with VCI were randomly divided into the treatment group [n = 75, VCI without dementia（VCIND） ：47, vascular dementia（VaD）：281 and the control group（n = 65, VCIND： 41, VaD： 24）. The control group received conventional therapy, while the treatment group were administrated orally with 20 gg of atorvastatin every evening. The indices of TC,TG, HDL-C,LDL-C,as well as the scores of MMSE and clock-drawing test were compared between the groups before and 24 weeks after treatment. Results The plasma TC, TG, LDL-C decreased and the scores of MMSE and clockdrawing test improved significantly in the treatment group. The improvement in the scores of MMSE and clock-drawing test was greater in the VCIND treatment group than in the VaD treatment group. Conclusion ：Atorvastatin may improve cognitive function in patient with VCI,especially in VCIND patients.