缺氧缺血性脑病新生儿血清TNF-α和sICAM-1变化及其临床意义被引量：13

Changes and clinical significance of serum tumor necrosis factor and intercelluar adhesion molecule-1 in neonates with hypoxic-ischemic encephalopathy

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摘要目的观察新生儿缺氧缺血性脑病(HIE)患儿血清肿瘤坏死因子-α(TNF-α)和可溶性细胞间黏附分子-1(sICAM-1)的水平变化,探讨其在HIE中的作用。方法应用酶联免疫吸附法(ELISA)检测58例HIE患儿血清TNF-α和sICAM-1的水平,其中中重度28例,轻度30例,并与20例正常新生儿对照,采用方差分析进行统计学分析。结果中重度及轻度HIE患儿血清TNF-α和sICAM-1水平均高于正常对照组,差异有统计学意义(P均<0.05);中重度HIE患儿与轻度HIE组比较,差异有统计学意义(P<0.05)。结论TNF-α和sICAM-1可能通过缺氧缺血后的免疫功能改变、炎症反应参与HIE患儿的病理过程,血清TNF-α和sICAM-1水平可作为HIE严重程度和预后判断的早期分子生物学指标。

作者柴斌英王海英华亚军

机构地区东南大学附属江阴医院儿科东南大学附属中大医院儿科

出处《临床儿科杂志》 CAS CSCD 北大核心 2010年第3期231-232,243,共3页 Journal of Clinical Pediatrics

关键词缺氧缺血性脑病肿瘤坏死因子-Α 可溶性细胞间黏附分子-1 hypoxic-ischemic encephalopathy tumor necrosis factor-α intercelluar adhesion molecule-1

分类号 R722.121 [医药卫生—儿科]

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