抗菌药物体外药动/药效学模型及其在抗菌药物研发中的应用

In vitro pharmacokinetic models and their applications in antibiotics research

抗菌药物体外药动/药效学模型(抗菌药物体外PK/PD模型)能够模拟抗菌药物在人体内的药代动力学过程及其杀灭细菌的动态药效学过程。用该方法研究抗菌药物与病原菌的作用比用一般稳态模型更符合体内的实际情况,同时该方法与动物感染模型相比也表现出很多优点。因此抗菌药物体外PK/PD模型在国外已经成为一种很常用的研究手段,但是在我国这种方法的采用却几乎还是空白。本文就国外抗菌药物体外PK/PD模型的基本结构、原理、发展、使用及其在抗菌药物研究开发中的应用进行综述。

The in vitro pharmacokinetic model can simulate the pharmacokinetic course of antibacterial drugs, which makes the research of drug-bacteria interaction more reliable than that with stable models. More over, the in vitro pharmacokinetic model is superior to animal infection models in many aspects. All of these make it a popular method broadly used in the antibiotics research in abroad; however, it＇s still a blank in our country. Here we review on the structures, principles, development and operations of the in vitro antibiotics pharmacokinetic models and its applications in the antibacterial drugs research.