2008年广州市20岁以上正常人群甲型肝炎抗体流行率调查

The Prevalent Rate of anti-HAV IgG in Normal Adults over 20 Years Old in Guangzhou in 2008

目的调查2008年广州市20岁以上正常人群甲型肝炎抗体(抗-HAV IgG)流行率。方法 2008年在广州市南方医院健康体检人群中,采集20岁以上5个年龄组正常人群血清500份,应用雅培(Abbott)公司抗-HAV IgG诊断试剂盒(化学发光法),定性检测血清中的抗-HAV IgG,分析人群中抗-HAV IgG流行率。结果 2008年广州市20岁以上正常人群抗-HAV IgG总流行率为72.2%(361/500),男性人群阳性率为73.2%(230/314),女性人群阳性率70.4%(131/186)。20～岁组、30～岁组、40～岁组、50～岁组和60岁以上组抗-HAV IgG阳性率分别为52.8%(56/106)、52.5%(63/120)、82.5%(94/114)、89.8%(88/98)和96.8%(60/62),随年龄增长而上升。结论目前广州市20～39岁组人群抗-HAV IgG阳性率较低,建议对该人群的易感者进行甲型肝炎疫苗免疫。

Objective To investigate the prevalent rate of anti-HAV IgG in normal adults over 20 years old in Guangzhou in 2008. Methods 500 sera were collected from normal adults for a routine medical examination in Nanfang Hospital in 2008. The Architect HAVAb-IgG （chemiluminescence method） was used for detection of anti-HAV IgG in serum,and the prevalent rates of anti-HAV IgG in the different age groups were evaluated. Results The prevalent rate of anti-HAV IgG in the population of age 20 in Guangzhou in 2008 was 72.2% （361 / 500）,in which 73.2% （230 / 314） for male,and 70.4%（131 / 186） for female. The prevalent rates of 20-,30-,40-,50-and ≥60 years age groups were 52.8% （56/106）,52.5% （63/120）,82.5% （94/114）,89.8% （88/98） and 96.8% （60 / 62）,respectively,with a trend of increasing with age. Conclusion At present,the prevalent rate of anti-HAV IgG is relatively low among the population age from 20 to 39 years old in Guangzhou. HAV vaccination should be recommended for the young adults susceptible to HAV infection.