摘要
目的:探讨帕罗西汀治疗脑卒中后抑郁的疗效及安全性。方法:将90例脑卒中后抑郁患者随机分为研究组46例,对照组44例,在脑卒中常规治疗及心理治疗基础上分别给予帕罗西汀和阿米替林治疗8周。于治疗前及治疗2、4、8周末采用汉密顿抑郁量表(HAMD)及爱丁堡斯堪地纳维亚神经功能缺失改良量表(MESSS)评定临床疗效。结果:研究组治疗2周末HAMD及MESSS量表评分均较治疗前显著下降(P<0.05),对照组4周末显著下降(P<0.05),两组间同期比较有显著性差异(P<0.05)。研究组较对照组不良反应少而轻。结论:帕罗西汀起效快,疗效显著,安全性高,是治疗脑卒中后抑郁的理想药物。
Objective：To explore the curative effect and safety of Paroxetine in the treat- ment of post - stroke depression. Methods： 90 patients were randomly divided into research group （ n = 46 ） taking routine treat- ment and psychotherapy combining Paroxe- tine and control group （ n = 44 ） combining amitriptyline for 8 weeks. Curative effects were assessed with the HAMD and the MESSS before treatment and at the ends of 2nd,4th and 8th week treatment. Results ： Compared with pretreatment, scores of both the HAMD and the MESSS significantly decreased at the end of the 2nd week in the research group（P 〈0. 05） and at the end of 4th week in the control group （ P 〈 0. 05 ）, comparisons of the 2 groups in the corre- sponding period showed significant difference （ P 〈 0. 05 ）. The research group had less and slight side effects than the control group. Conclusion： Paroxetine is an ideal medicine takeing effect faster and has nota- ble curative effect, higher safety in the treat- ment of post - stroke depression.
