磁共振R_2~＊值评估兔肝纤维化模型的初步实验研究

Preliminary Experimental Study of MRI R_2~＊ in Evaluating Rabbit Hepatic Fibrosis Model

目的探讨磁共振R2*值评价兔肝纤维化的可行性。材料与方法分别对38只肝纤维化模型兔和8只正常兔行MR常规扫描及血氧水平依赖功能磁共振成像(BOLD-fMRI),以病理学肝纤维化分期为基础将其划分为:A组:无肝纤维化组,B组:轻/中度纤维化组,C组:重度纤维化/肝硬化组,比较各组间R2*平均值的变化情况。结果随着肝纤维化分期进展,R2*平均值逐渐增大。经统计学分析,A、B组与C组间的差异有统计学意义(P<0.05)。结论 BOLD-fMRI虽不能敏感诊断早期肝纤维化以及对肝纤维化进行分级分期,但所得的R2*值随肝纤维化分期进展而增大,从而能够反映肝脏血氧含量变化以及肝纤维化严重程度,可作为一种指导临床诊疗的有效手段。

Objective To investigate the feasibility of MRI R2＊ in evaluating rabbit hepatic fibrosis.Materials and Methods Thirty-eight rabbits with hepatic fibrosis and 8 normal rabbits were performed conventional MR and BOLD fMRI.The rabbits were divided into 3 groups base on pathological stage.Group A：no hepatic fibrosis group,group B：mild / moderate fibrosis group,group C：severe fibrosis / cirrhosis group.The average value of R2＊ among groups were compared.Results R2＊ values were gradually increased with the severity of liver fibrosis.There were significant difference of R2＊ values between group A and group C,as well as group B and group C（P0.05）.Conclusion Although BOLD fMRI is not sensitive to early stage of hepatic fibrosis,the R2＊ value increased with the severity of fibrosis,which reflected the change of oxygen content and the fibrosis severity.BOLD fMRI can be an effective method to guide clinical diagnosis and treatment.