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应用HC-Ⅱ法筛查宫颈病变的临床评价 被引量:2

Application of Hybrid Capture II Method of Laboratory Evaluation of Screening for Cervical Lesions
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摘要 目的 探讨高危型HPV病毒和宫颈病变的相关性,分析运用HC-Ⅱ法筛查宫颈病变的临床应用评价.方法 应用非配对病例对照研究方法,统计分析在佛山中医院宫颈病-宫颈癌筛查防治中心同时做病理活体组织检查和HR-HPV DNA检测的893例病例.依据病理组织检查结果,分为无宫颈病变的正常组(对照组)和有宫颈病变的病变组.宫颈病变包括CIN-Ⅰ,CIN-Ⅱ,CIN-Ⅲ和SCC.对照分析全部资料的HR-HPV DNA结果,单因素分析HR-HPV与宫颈病变的相关性,统计HC-Ⅱ法筛查宫颈病变的灵敏度、特异度、阳性预测值和阴性预测值.结果 组病例HR-HPV DNA阳性率分别是:正常组32.18%(223/693),CIN-Ⅰ 53.66%(66/123),CIN-Ⅱ 78.72%(37/47),CIN-Ⅲ 93.10%(27/29)和SCC组100.00%(1/1).各级病变与HR-HPV感染的比值比(OR)、归因危险度百分比(PAR%)分别是:CIN-Ⅰ级2.44,31.64%;CIN-Ⅱ级7.80,69.12%;CIN-Ⅲ级28.46,90.48%;高度瘤样变(CIN-Ⅱ及CIN-Ⅲ)11.42,72.73%.HC-Ⅱ法筛查宫颈病变的灵敏度为65.51%,特异度为67.83%,阳性预测值为36.81%和阴性预测值为87.19%.结论 高危型HPV感染与宫颈上皮瘤样变的发生密切相关,随宫颈病变程度的加重,相关性增加,感染率也增加;HC-Ⅱ筛查方法的最大价值在于对宫颈病变的阴性预测值,筛选出易患宫颈病变的高危人群. Objective To explore high-risk HPV virus and the relationship between cervical lesions,and analyse the use of HC-II method of laboratory evaluation of screening for cervical lesions. Methods Application of non-matched case-control study, statistical analysis of cervical disease in Foshan hospital-prevention and treatment of cervical cancer screening center at the same time to do pathology biopsy and HR-HPV DNA detection of 893 cases. Based on the results of histopathological examination,no cervical lesions were divided into normal group (control group),there were cases of cervical lesions group. Cervical lesions,including CIN-I ,CIN-II ,CIN-III and SCC. Comparative analysis of all the information the results of HR-HPV DNA,single-factor analysis of HR-HPV and cervical lesions associated statistical HC-II method of screening for cervical lesions sensitivity, specificity, positive predictive value and negative predictive value. Results Patients in each group HR-HPV DNA positive rates were as follows : normal group 32.3 % (223/693), CIN-I 53.7 % (66/123), CIN-II 78.7% (37/47),CIN-III 93.1% (27/29) and SCC group 100% (1/1). Lesions at all levels of HR-HPV infection with odds ratio (OR) ,attributable risk percent (PAR % ) were :CIN-I level 2.44,31.64 % ;CIN-II-class 7.80,69.12 % ;CIN-III- class 28.46,90. 48% ;a high degree of CIN (CIN-II and III) 11.42,72. 730/00. HC-II method of the sensitivity of screening for cervical lesions was 66.5% ,the specificity was 67.8% ,positive predictive value was 37.0% and negative predictive val- ue of 87.2%. Conclusion High-risk HPV infection and cervical intraepithelial neoplasia was closely related to the occur- rence of change. With the severity of cervical disease,the relevance of increased rate of infection had also increased. HC-II screening methods of the greatest value lies in the negative predictive value of cervical lesions ,filter out high-risk groups susceptible to cervical lesions.
出处 《现代检验医学杂志》 CAS 2010年第5期85-87,共3页 Journal of Modern Laboratory Medicine
基金 佛山市卫生局课题《高危型HPV定量检测在宫颈癌及癌前病变筛查中的作用》内容,课题号:2004416.
关键词 HC-Ⅱ基因杂交信号放大技术 子宫颈上皮瘤样变 人乳头瘤病毒 genetic hybrid capture signal amplification technology cervical intraepithelial neoplasia human papillomavirus
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参考文献8

  • 1赵方辉,李楠,马俊飞,张洵,吴令英,戎寿德,Lorincz A,Belinson J,乔友林.山西省襄垣县妇女人乳头状瘤病毒感染与宫颈癌关系的研究[J].中华流行病学杂志,2001,22(5):375-378. 被引量:209
  • 2Bohmer G,van den Brule AJ,Brummer O,et al.No confirmed case of human papillomavirus DNA negative cervical intraepithelial neoplasia grade 3 or invasive primary cancer of the uterine cervix among 511 patients[J].Am J Obstet Gynecol,2003,189(1):118-120.
  • 3Clifford GM,Smith JS.Plummer M,et al.Human papillomavirus types in invasive cervical cancer worldwide a meta analysis[J].Br J Cancer,2003,88(1):63-73.
  • 4郎景和.迎接子宫颈癌预防的全球挑战与机遇[J].中华妇产科杂志,2002,37(3):129-131. 被引量:884
  • 5Schiffiman M,Herrero R,Hidesheim A,et al.HPV DNA testing in cervical cancer screening results from woman in a high-risk Province of Costa Rica[J].JAMA,2000,283(1):87-93.
  • 6Ledger WJ,Jeremias J,Witkin SS,et al.Testing for high-risk human papillomavirus types will become a standard of clinical care[J].Am J Obstet Gynecol,2000,182(4):860-865.
  • 7乔友林,章文华,李凌,潘秦镜,杨玲,吴令英,戍寿德,李爱玲,张询,任生达,Belinson J.子宫颈癌筛查方法的横断面比较研究[J].中国医学科学院学报,2002,24(1):50-53. 被引量:351
  • 8Cuzik J.HPV testing primary cervical canser screening[J].JAMA,2000,283(1):108-109.

二级参考文献5

  • 1李洁,刘宝印,zur Hausen H,王宏,杨学志,李力,刘文,刘洪隐,陆克昭,刘旭,牛春燕,裴润芳,苏钟浦,王言贵,董继华,张桂宁,刘春杰,许吉林,林毓纯.中国妇女宫颈癌组织中人乳头瘤病毒感染及其地理分布的调查[J].中华实验和临床病毒学杂志,1996,10(1):50-55. 被引量:67
  • 2卫生部肿瘤防治研究办公室.中国恶性肿瘤死亡调查研究[M].北京:人民卫生出版社,1979,1..
  • 3Belinson J,Int J Gynecol Cancer,1999年,9卷,411页
  • 4李洁,中华实验和临床簿学杂志,1996年,10卷,50页
  • 5Peng H,Int J Cancer,1991年,47卷,711页

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