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Molecular basis of the first cell fate determination in mouse embryogenesis 被引量:1

Molecular basis of the first cell fate determination in mouse embryogenesis
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摘要 Through proliferation and differentiation, a single cell, the zygote, can give rise to a complex organism composed of many types of cells. Up to the eight-cell embryo stage, the blastomeres are morphologically identical and distributed symmetrically in the mammalian embryo. Functionally, in some species, they are all totipotent. However, due to the compaction of blastomeres and the asymmetrical cell division at the late phase of the eight-cell embryo, the blastomeres of the morula are no longer identical. During the transition from morula to blastocyst, blastomeres differentiate, resulting in the first cell fate decision in embryogenesis, namely, the segregation of the inner cell mass and the tropheetoderm. In this review, we will discuss the regulatory mechanisms essential for the cell fate choice during blastocyst development, including transcriptional regulation, epigenetic regulation, mieroRNAs, and signal transduction.
出处 《Cell Research》 SCIE CAS CSCD 2010年第9期982-993,共12页 细胞研究(英文版)
关键词 inner cell mass TROPHECTODERM EMBRYOGENESIS 胚胎发育 分子基础 单元格 小鼠 哺乳动物胚胎 单细胞 卵裂球 细胞组成
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