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血浆内源性阿片肽对冠心病患者等长收缩运动心血管反应的调控 被引量:5

Effects of plasma endogenous opioids on cardiovascular regulation during isometric exercise in patients with coronary artery disease
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摘要 目的:探讨血浆内源性阿片肽(EOPs)对等长收缩运动(IE)心血管反应的调控机制及其与心肌缺血的关系。方法:冠心病人运动试验阴性组(ESN组,10名)和运动试验阳性组(ESP组,10名),以及正常人(NOR组,10名)进行最大短暂等长收缩运动(BIE)、最大持续等长收缩运动(SIE)及分级卧位踏车运动(DE),观察EOPs变化及心血管反应。结果:从总体上EOPs运动反应表现为SIE>BIE>DE;各阶段各组间EOPs反应的趋势相似。正常人心率、血压、两项乘积、射血分数(EF)、短轴缩短率(SF)和E/A表现为DE>SIE>BIE。结论:冠心病人IE的血浆EOPs反应与正常人类似;IE的血浆EOPs释放与心肌缺血无直接关联;IE,尤其是SIE时中枢命令较强,血浆EOPs释放较多,可能有助于降低交感神经兴奋性,减少冠心病人的运动风险。 Objective: To explore effects of plasma endogenous opioids peptides (EOPs) during isometric exercise (IE) on cardiovascular regulation and to study the relationship between EOPs release and myocardial ischemia. Method:EOPs concentrations and cardiovascular response were compared during brief maximal isometric exercise (BIE), sustained maximal isometric exercise (SIE) and dynamic exercise(DE,it′s graded supine bicycle exercise). The subjects included 10 normal subjects (NOR, n=10) and 20 patients with coronary artery diseases (CAD) who were either exercise stress testing negative patients (ESN, n=10) or exercise stress testing positive patients (ESP, n=10). Result: In general, EOPs exercise responses featured SIE>BIE>DE;There were no significant differences in the trend of EOPs and cardiovascular exercise responses among different exercises and groups. Conclusion:①The EOPs responses to IE were similar in patients with CAD and in normal subjects. ② EOPs release during IE was irrelevant to myocardial ischemia. ③ Strong central command during IE, especially SIE, resulted in significant release of plasma EOPs, which might help to weaken sympathetic activity, thus reducing the risk of exercise accident in patients with CAD.
出处 《中国康复医学杂志》 CAS CSCD 1999年第2期50-54,共5页 Chinese Journal of Rehabilitation Medicine
基金 江苏省科委自然科学基金
关键词 等长收缩运动 冠心病 心血管反应 EOPs Isometric exercise Endogenous opioids Coronary artery disease Cardiovascular response
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