骨骼肌组织工程支架材料的研究进展

RESEARCH PROGRESS OF SCAFFOLD MATERIALS IN SKELETAL MUSCLE TISSUE ENGINEERING

目的综述骨骼肌组织工程支架材料的研究现状,展望骨骼肌组织工程支架材料的发展方向。方法查阅近年来关于骨骼肌组织工程支架材料的相关文献,并从骨骼肌组织工程支架材料的种类、特性、制备技术、生物相容性等方面进行回顾及综合分析。结果骨骼肌组织工程支架材料种类繁多,大致可分为无机生物材料、生物可降解合成高分子材料、天然可降解生物材料和复合材料等4种,对不同特性的支架材料,制备工艺不同,制备出的支架各有其结构和功能优势,可根据不同的研究需求进行选择。结论复合材料的应用、复合支架的制备以及根据支架材料所需特定功能对其表面进行改性,是骨骼肌组织工程支架材料应用的发展方向。

Objective To review the current researches of scaffold materials for skeletal muscle tissue engineering,to predict the development trend of scaffold materials in skeletal muscle tissue engineering in future.Methods The related literature on skeletal muscle tissue engineering,involving categories and properties of scaffold materials,preparative technique and biocompatibility,was summarized and analyzed.Results Various scaffold materials were used in skeletal muscle tissue engineering,including inorganic biomaterials,biodegradable polymers,natural biomaterial,and biomedical composites.According to different needs of the research,various scaffolds were prepared due to different biomaterials,preparative techniques,and surface modifications.Conclusion The development trend and perspective of skeletal muscle tissue engineering are the use of composite materials,and the preparation of composite scaffolds and surface modification according to the specific functions of scaffolds.