部分麻醉镇痛药物的电喷雾质谱研究

Studies on Electrospray Mass Spectrometry of Some Narcotic Drugs

近年来，电喷雾质谱作为一种新的软电离技术，广泛应用于生物和药物领域［１～３］，特别是电喷雾电离与多级串联质谱技术的联用，使药物化学及其药代动力学的研究发生了日新月异的变化［４～６］．以往人们曾利用化学电离质谱中的特殊反应及快原子轰击质谱中的某些加合反...

Using electrospray ionization(ESI) and tandem mass spectrometry techniques, the protonic positions in protonated molecular ions of some narcotic drugs were studied. The data of ESI/MS\+\%n\% experiments of morphine and deuterium\|loaded morphine were first discussed. The protonic position was considered to locate on oxygen atom of cyclic ether in morphine molecular. Compared with the same and different ions among morphine, codeine, acetylcodeine and dihydrocodeine, the protonic positions in protonated molecular ions of these compounds were further determined. The fragmentation mechanism of morphine in ESI/MS\+\%n\% experiments was also repored in the paper, and there were similar dehydrolysis mechanism in gas phase or in liquid phase for morphine.