摘要
目的探讨老年复治肺结核患者的耐药特点。方法通过对2007年6月~2010年6月在我院治疗的88例老年(≥60岁)复治痰菌阳性的肺结核患者做耐药分析和研究。另外随机抽取80例年青组(<60岁)的复治菌阳的患者作为对照组,对比两者间耐药例数。结果 老年患者对一线药物的耐药顺序:异烟肼(INH)>链霉素(SM)>利福平(RFP)>乙胺丁醇(EMB)。在二线药物中耐药率相对低的有莫西沙星,阿米卡星和克拉霉素。在二线药物的耐药顺序为:力克肺疾>利福布汀>Th1321>左氧氟沙星>莫西沙星,阿米卡星>克拉霉素。复治肺结核患者中,老年组与年青组的耐药率之间有显著性差异(p<0.01)。老年复治肺结核患者的耐药例数为41例,耐药率达46.6%。结论正确认识老年复治肺结核患者的耐药特点,广泛开展耐药检验分析,对治疗老年肺结核患者具有重要的临床价值。
Objective Probe into the characteristics of drug resistance in retreated pulmonary tuberculosis in elderly patients.Methods From June 2007 to June 2010 in our hospital 88 cases of elderly(≥ 60 years) inpatients with sputum-positive retreated pulmonary tuberculosis had been drug resistance analyzed and research.Another 80 cases were randomly selected young(60 years) re-treated positive bacteria patients as the control group,compared the number of cases between the two resistance.Results In elderly patients the order of resistance to first-line drug:isoniazid(INH) streptomycin(SM) rifampicin(RFP) ethambutol(EMB).In the second-line drugs have relatively low resistance rates of moxifloxacin,amikacin and clarithromycin.Second-line drug resistance in order:PasiniazideRifabutinTh1321levofloxacinmoxifloxacin,amikacinclarithromycin.In retreated pulmonary tuberculosis patients,the difference between resistance rates of elderly group and younger group were significantly(p0.01).Elderly patients with pulmonary tuberculosis have 41 cases resistant to drug,resistance rate is 46.6%.Conclusion Correct understand drug resistance of elderly patients with pulmonary tuberculosis,extensively drug tests and analysis have important clinical value to the treatment of elderly patients with pulmonary tuberculosis.
出处
《现代医院》
2010年第12期76-77,共2页
Modern Hospitals
关键词
老年
复治肺结核
耐药
Elderly
Retreated pulmonary tuberculosis
Resistance